| Name | c Myc |
|---|---|
| Synonyms | MYC; Myc proto oncogene protein; Oncogene MYC; Transcription factor p64; c Myc; v myc avian myelocytomatosis viral oncogene homolog; v myc myelocytomatosis viral oncogene homolog (avian); Myc proto oncogene proteins… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10630619 | Wang C, Youssef J, Saran B, Rothberg PG, Cunningham ML, Molteni A, Badr M: Diminished energy metabolism and enhanced apoptosis in livers of B6C3F1 mice treated with the antihepatocarcinogen rotenone. Mol Cell Biochem. 1999 Nov;201(1-2):25-32. Furthermore, rotenone increased the expression of c-myc mRNA to 5-fold of control values within 3 days, an effect which was still observed (3-fold) after 7 days. |
6(0,0,1,1) | Details |
| 9270009 | Gerhauser C, Lee SK, Kosmeder JW, Moriarty RM, Hamel E, Mehta RG, Moon RC, Pezzuto JM: Regulation of ornithine decarboxylase induction by deguelin, a natural product cancer chemopreventive agent. Cancer Res. 1997 Aug 15;57(16):3429-35. ODC activity was also inhibited by bullatacin and various antimitotic agents (podophyllotoxin, vinblastine, and colchicine), but only deguelin and bullatacin were active as inhibitors of ODC levels in a TPA-independent c-Myc-mediated induction system using cultured BALB/c c-MycER cells. These results suggest that antimicrotubule effects, as mediated by rotenone, for example, are not responsible for inhibitory activity facilitated by deguelin. |
2(0,0,0,2) | Details |
| 14649730 | Conn KJ, Ullman MD, Larned MJ, Eisenhauer PB, Fine RE, Wells JM: cDNA microarray analysis of changes in gene expression associated with MPP+ toxicity in SH-SY5Y cells. Neurochem Res. 2003 Dec;28(12):1873-81. RT-PCR analysis of a subset of genes showed that c-Myc and RNA-binding protein 3 (RMB3) expression decreased by approximately 50% after 72 h of exposure to MPP+ (1 mM) but did not change after 72 h of exposure to (25 microM), rotenone (50 nM), and peroxide (600 microM). In contrast, c-Myc expression was slightly increased in RA-differentiated cells. |
1(0,0,0,1) | Details |