| Name | aldehyde dehydrogenase (protein family or complex) |
|---|---|
| Synonyms | aldehyde dehydrogenase; aldehyde dehydrogenases |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3126046 | Rizzoli VA, Rossi CR: oxidation in rat liver mitochondria, action of Mg2+, ATP and rotenone on oxidation in intact mitochondria, and on some purified aldehyde dehydrogenase isozymes. Enzyme. 1988;39(1):28-43. |
112(1,2,2,2) | Details |
| 1759390 | Medvedev AE, Gorkin VZ: [The role of monoamine oxidase in the regulation of mitochondrial energy functions]. Vopr Med Khim. 1991 Sep-Oct;37(5):2-6. Incubation of aldehyde dehydrogenase-free mitochondrial preparations with biogenic amines and resulted in inhibition of enzymes activity of both outer (rotenone-insensitive -cytochrome c reductase) and inner (succinate dehydrogenase, cytochrome c reductase) mitochondrial membranes. |
31(0,1,1,1) | Details |
| 4149764 | Tottmar SO, Pettersson H, Kiessling KH: The subcellular distribution and properties of aldehyde dehydrogenases in rat liver. Biochem J. 1973 Dec;135(4):577-86. |
3(0,0,0,3) | Details |
| 178668 | Denk H, Moldeus PW, Schulz RA, Schenkman JB, Keyes SR, Cinti DL: Hepatic organelle interaction. J Cell Biol. 1976 Jun;69(3):589-98. The apparent stimulation by of accumulation in the medium, which was reported to occur with liver slices and homogenates as well as with mitochondria plus microsomes, has been shown to be the result of inhibition of mitochondrial aldehyde dehydrogenase. |
2(0,0,0,2) | Details |
| 176156 | Cinti DL, Keyes SR, Lemelin MA, Denk H, Schenkman JB: Biochemical properties of rat liver mitochondrial aldehyde dehydrogenase with respect to oxidation of J Biol Chem. 1976 Mar 25;251(6):1571-7. The respiratory chain inhibitors, rotenone, and antimycin A plus strongly inhibited oxidation by apparently the same mechanism, although the crude enzyme preparation (freed from the membrane) was slightly sensitive to rotenone. |
2(0,0,0,2) | Details |
| 15377162 | Meyer MJ, Mosely DE, Amarnath V, Picklo MJ Sr: Metabolism of 4--trans-2-nonenal by central nervous system mitochondria is dependent on age and NAD+ availability. Chem Res Toxicol. 2004 Sep;17(9):1272-9. Rotenone (100 nM) inhibited respiration by 15% whereas HNEAcid formation was decreased to 72% of control levels. We then tested the hypothesis that the mitochondrial /NAD (+) ratio regulated matrix aldehyde dehydrogenase activity. |
1(0,0,0,1) | Details |
| 10797558 | Lamensdorf I, Eisenhofer G, Harvey-White J, Hayakawa Y, Kirk K, Kopin IJ: Metabolic stress in PC12 cells induces the formation of the endogenous dopaminergic neurotoxin, 3,4-dihydroxyphenylacetaldehyde. J Neurosci Res. 2000 May 15;60(4):552-8. This is either oxidized to 3,4- by aldehyde dehydrogenase, an NAD-dependent enzyme or reduced to 3, 4-dihydroxyphenylethanol (DOPET) by or aldose reductase. |
1(0,0,0,1) | Details |
| 10854571 | Lamensdorf I, Eisenhofer G, Harvey-White J, Nechustan A, Kirk K, Kopin IJ: 3,4-Dihydroxyphenylacetaldehyde potentiates the toxic effects of metabolic stress in PC12 cells. Brain Res. 2000 Jun 23;868(2):191-201. This is mainly oxidized to 3,4- by aldehyde dehydrogenase (ALDH), but is also partly reduced to 3, 4-dihydroxyphenylethanol (DOPET) by or aldose reductase (ARs). In a previous study, we found that rotenone, a complex I inhibitor, induced a rapid accumulation of DOPAL and DOPET in the medium of cultured PC12 cells. |
1(0,0,0,1) | Details |
| 562603 | Thurman RG, Brentzel HJ, McKenna WR: Common mechanism for the adaptive increase in hepatic and metabolism due to chronic pretreatment with Adv Exp Med Biol. 1977;85A:237-45. uptake in both -treated and control livers was similarly sensitive to inhibition by 4-methylpyrazole, rotenone, and antimycin A. As a consequence of these events, a greater rate of reoxidation occurs, resulting in a greater rate of production of NAD+ which stimulates oxidation via alcohol dehydrogenase and oxidation via aldehyde dehydrogenase (s). |
1(0,0,0,1) | Details |
| 15377279 | Kollau A, Hofer A, Russwurm M, Koesling D, Keung WM, Schmidt K, Brunner F, Mayer B: Contribution of aldehyde dehydrogenase to mitochondrial bioactivation of nitroglycerin: evidence for the activation of purified soluble guanylate cyclase through direct formation of Biochem J. 2005 Feb 1;385(Pt 3):769-77. Lack of effect of the mitochondrial poisons, rotenone and myxothiazol, suggested that reduction by components of the respiratory chain is not essential to sGC activation. |
1(0,0,0,1) | Details |
| 956168 | Hasumura Y, Teschke R, Lieber CS: Characteristics of oxidation in rat liver mitochondria. . J Biol Chem. 1976 Aug 25;251(16):4908-13. By contrast, the activity of aldehyde dehydrogenase in disrupted mitochondria remained unchanged. By contrast, metabolism was virtually abolished by rotenone and antimycin A. |
1(0,0,0,1) | Details |
| 17010440 | Leiphon LJ, Picklo MJ Sr: Inhibition of detoxification in CNS mitochondria by fungicides. Neurotoxicology. 2007 Jan;28(1):143-9. Epub 2006 Sep 1. In this present study, we examined the potential of multiple agricultural pesticides for their ability to inhibit the function of whole, respiring rat brain mitochondria using the oxidation of the lipid- (HNE) as a biomarker for mitochondrial aldehyde dehydrogenase (ALDH) activity in situ. These compounds included rotenone, maneb, mancozeb, and benomyl. |
1(0,0,0,1) | Details |