| Name | ND2 |
|---|---|
| Synonyms | MT ND2; MTND 2; MTND2; NADH dehydrogenase 2; NADH dehydrogenase subunit 2; NADH ubiquinone oxidoreductase chain 2; ND2; mitochondrially encoded NADH dehydrogenase 2… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15950924 | Mus F, Cournac L, Cardettini V, Caruana A, Peltier G: Inhibitor studies on non-photochemical plastoquinone reduction and H (2) photoproduction in Chlamydomonas reinhardtii. Biochim Biophys Acta. 2005 Jul 15;1708(3):322-32. Based on the insensitivity of these reactions to rotenone, a type-I NADH dehydrogenase (NDH-1) inhibitor, and their sensitivity to flavoenzyme inhibitors and thiol blocking agents, we conclude to the involvement of a type-II NADH dehydrogenase (NDH-2) in PQ reduction. |
81(1,1,1,1) | Details |
| 8833408 | Matsunaga T, Kudo J, Takahashi K, Dohmen K, Hayashida K, Okamura S, Ishibashi H, Niho Y: Rotenone, a mitochondrial NADH dehydrogenase inhibitor, induces cell surface expression of CD13 and CD38 and apoptosis in HL-60 cells. Leuk Lymphoma. 1996 Feb;20(5-6):487-94. Since this finding suggested that ND2 gene expression was related to myeloid differentiation, we here investigated the effects of rotenone, a specific NADH dehydrogenase inhibitor, on HL-60 cell growth, differentiation and death. |
32(0,1,1,2) | Details |
| 3378042 | Yagi T, Hon-nami K, Ohnishi T: Purification and characterization of two types of -quinone reductase from Thermus thermophilus HB-8. Biochemistry. 1988 Mar 22;27(6):2008-13. The - reductase activity of the isolated NADH dehydrogenase 2 was about 30-fold as high as that of the dodecyl beta-maltoside extract and rotenone insensitive. |
7(0,0,1,2) | Details |
| 20074573 | Nakamaru-Ogiso E, Han H, Matsuno-Yagi A, Keinan E, Sinha SC, Yagi T, Ohnishi T: The ND2 subunit is labeled by a photoaffinity analogue of asimicin, a potent complex I inhibitor. FEBS Lett. 2010 Mar 5;584(5):883-8. Epub 2010 Jan 13. The cross-linking was blocked by rotenone. |
3(0,0,0,3) | Details |
| 12079358 | Cardol P, Matagne RF, Remacle C: Impact of mutations affecting ND mitochondria-encoded subunits on the activity and assembly of complex I in Chlamydomonas. J Mol Biol. 2002 Jun 21;319(5):1211-21. The mitochondrial rotenone-sensitive NADH:ubiquinone oxidoreductase (complex I) comprises more than 35 subunits, the majority of which are encoded by the nucleus. In Chlamydomonas reinhardtii, only five components (ND1, ND2, ND4, ND5 and ND6) are coded for by the mitochondrial genome. |
1(0,0,0,1) | Details |
| 18291703 | Dlaskova A, Hlavata L, Jezek P: Oxidative stress caused by blocking of mitochondrial complex I H (+) pumping as a link in aging/disease vicious cycle. Int J Biochem Cell Biol. 2008;40(9):1792-805. Epub 2008 Jan 19. H (+) pumping may be attenuated by high protonmotive force or inhibited by oxidative stress-related mutations of ND5 (ND2, ND4) subunit. Rotenone caused a 5-fold J (m) increase (AC (50) 2 microM), which was attenuated by uncoupling, membrane potential (DeltaPsi (m)), and DeltapH-collapse, since addition of FCCP (IC (50) 55 nM), valinomycin, and nigericin prevented this increase. |
1(0,0,0,1) | Details |
| 10220277 | Konishi K, Tanaka T: Inhibitory effects of tannins on the NADH dehydrogenase activity of bovine heart mitochondrial complex I. Biol Pharm Bull. 1999 Mar;22(3):240-3. -quinone oxidoreductase is classified into two groups, NADH dehydrogenase-1 (NDH-1) and NADH dehydrogenase-2 (NDH-2). Although many specific inhibitors of NDH-1 (e.g. rotenone and piericidin A) have been reported, the reactive sites are at or near to, the -binding site. |
1(0,0,0,1) | Details |
| 2050655 | Yagi T: Bacterial -quinone oxidoreductases. . J Bioenerg Biomembr. 1991 Apr;23(2):211-25. The - reductase activities of NDH-1 are inhibited by rotenone, and dicyclohexylcarbodiimide. |
0(0,0,0,0) | Details |