Protein Information

Name 1 alpha hydroxylase
Synonyms 1 alpha hydroxylase; VDR; CYP 1; CYP1; 1 alpha hydroxylase deficiency; 25 hydroxyvitamin d3 1 alpha hydroxylase; 25 OHD 1 alpha hydroxylase; 25 hydroxycholecalciferol 1 hydroxylase deficiency…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
3281665 Hagenfeldt Y, Pedersen JI, Bjorkhem I: Properties of guinea-pig kidney 25-hydroxyvitamin D3 1 alpha-hydroxylase assayed by isotope dilution-mass spectrometry. Biochem J. 1988 Mar 1;250(2):521-6.

Mitochondrial respiratory-chain inhibitors (cyanide, rotenone, antimycin A) had no effect on the hydroxylation.
4(0,0,0,4) Details
3355535 Pedersen JI, Hagenfeldt Y, Bjorkhem I: Assay and properties of 25-hydroxyvitamin D3 23-hydroxylase. Biochem J. 1988 Mar 1;250(2):527-32.

Fasting the animals for 24 h induced the 23-hydroxylase almost as efficiently as treatment with 1,25-dihydroxyvitamin D3, with a concomitant depression of the 1 alpha-hydroxylase.
It was stimulated by the respiratory-chain inhibitors rotenone, antimycin A and KCN.
1(0,0,0,1) Details