Protein Information

Name ferrochelatase
Synonyms EPP; FCE; FECH; Ferrochelatase; Ferrochelatase (protoporphyria); Heme synthase; Heme synthetase; Iron chelatase…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
17196160 Yamamoto F, Ohgari Y, Yamaki N, Kitajima S, Shimokawa O, Matsui H, Taketani S: The role of nitric oxide in delta-aminolevulinic acid (ALA)-induced photosensitivity of cancerous cells. Biochem Biophys Res Commun. 2007 Feb 16;353(3):541-6. Epub 2006 Dec 22.

The levels of mitochondrial ferrochelatase and rotenone-sensitive NADH dehydrogenase in the NOS2-induced cells decreased.
6(0,0,1,1) Details
5500305 Jones MS, Jones OT: Ferrochelatase of Rhodopseudomonas spheroides. Biochem J. 1970 Sep;119(3):453-62.

Fe (2+) is not incorporated aerobically into porphyrins unless an electron donor, succinate or NADH, is supplied; the low aerobic rate of metalloporphyrin synthesis obtained is insensitive to rotenone and antimycin.
3(0,0,0,3) Details
4345350 Barnes R, Connelly JL, Jones OT: The utilization of iron and its complexes by mammalian mitochondria. . Biochem J. 1972 Aug;128(5):1043-55.

These results suggest that the reduction of ferric iron and its complexes occurs inside the inner mitochondrial membrane in proximity to ferrochelatase.
The reduction was insensitive to rotenone or antimycin A.
1(0,0,0,1) Details