| Name | beta catenin |
|---|---|
| Synonyms | Beta catenin; CTNNB; CTNNB 1; CTNNB1; Catenin beta; Catenin beta 1; OK/SW cl.35; PRO2286… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19861544 | Rodenberg JM, Brown PH: A novel look into estrogen receptor-negative breast cancer prevention with the natural, multifunctional signal transduction inhibitor deguelin. Cancer Prev Res (Phila Pa). 2009 Nov;2(11):915-8. Epub 2009 Oct 27. These investigators showed that deguelin inhibits wnt/beta-catenin signaling in breast cancer cell lines, in addition to inhibiting other previously reported signaling pathways. |
1(0,0,0,1) | Details |
| 19861542 | Murillo G, Peng X, Torres KE, Mehta RG: Deguelin inhibits growth of breast cancer cells by modulating the expression of key members of the Wnt signaling pathway. Cancer Prev Res (Phila Pa). 2009 Nov;2(11):942-50. Epub 2009 Oct 27. The microarray profile indicated differential expression of two independent pathways, including clusters of apoptosis and Wnt/beta-catenin signaling genes in cells as a result of deguelin treatment. |
1(0,0,0,1) | Details |
| 16287083 | Taddei ML, Chiarugi P, Cuevas C, Ramponi G, Raugei G: Oxidation and inactivation of low molecular weight protein tyrosine phosphatase by the anticancer drug Aplidin. Int J Cancer. 2006 Apr 15;118(8):2082-8. Our data show that LMW-PTP is oxidized and inactivated during Aplidin treatment, thus causing a hyper-phosphorylation of its substrate beta-catenin. Rotenone, but not other selective inhibitors of ROS production, blocks the induction of ROS, suggesting the involvement of the mitochondrial respiratory chain in Aplidin action. |
1(0,0,0,1) | Details |