Protein Information

Name NDUFS3
Synonyms CI 30KD; Complex I 30KD; NADH dehydrogenase (ubiquinone) Fe S protein 3 (30kD) (NADH coenzyme Q reductase); NADH ubiquinone oxidoreductase 30 kDa subunit; NADH ubiquinone oxidoreductase Fe S protein 3; NDUFS 3; NDUFS3; Complex I 30KDs…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
18485875 Martinvalet D, Dykxhoorn DM, Ferrini R, Lieberman J: Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death. Cell. 2008 May 16;133(4):681-92.


Here we find that GzmA accesses the mitochondrial matrix to cleave the complex I protein NDUFS3, an iron-sulfur subunit of the NADH:ubiquinone oxidoreductase complex I, after Lys56 to interfere with NADH oxidation and generate superoxide anions.
2(0,0,0,2) Details