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Antosiewicz J, Damiani E, Jassem W, Wozniak M, Orena M, Greci L: Influence of structure on the antioxidant activity of indolinic nitroxide radicals. Free Radic Biol Med. 1997;22(1-2):249-55.
Three distinct indolinic nitroxides were synthesized and compared with vitamin E and Trolox (a hydrophilic analogue of vitamin E), where the only difference between the nitroxides was the length of the hydrocarbon chain in the 2-position of indole, namely 2 (C2), 10 (C10), and 18 (C18) carbons.
Mitochondrial rotenone-sensitive NADH oxidase and succinate oxidase responded differently to BuOOH-induced radical chemistry, and the compounds under study also protected the activity of the two enzymes but to different extents. |
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