Protein Information

Name aspartate aminotransferase
Synonyms Aspartate Aminotransferase 1; GIG18; GOT 1; GOT1; Aspartate aminotransferase; Glutamate oxaloacetate transaminase 1; Transaminase A; Aspartate aminotransferases…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
3758838 Tomasiak M: The importance of aspartate aminotransferase for platelet aggregation. Haematologia. 1986;19(2):101-12.

Other metabolic blockers, i.e. dinitrophenol (DNP), rotenone and antimycin also inhibited the aggregation of platelets, and a synergism has been demonstrated between DNP, rotenone and antimycin A action on platelet aggregation and blockade of aspartate aminotransferase activity.
85(1,1,1,5) Details
10425713 Obungu VH, Kiaira JK, Njogu RM, Olembo NK: Catabolism of proline by procyclic culture forms of Trypanosoma congolense. Comp Biochem Physiol B Biochem Mol Biol. 1999 May;123(1):59-65.

Rotenone had no effect on the rate of respiration except when the intact cells were first permeabilized by digitonin after which rotenone decreased the rate of respiration by 20-30%.
Activities of 1-pyrroline-5 carboxylate dehydrogenase, glutamate dehydrogenase, aspartate aminotransferase and NAD-linked malic enzyme were detectable but lower.
1(0,0,0,1) Details
16662651 Wiskich JT, Day DA: Malate Oxidation, Rotenone-Resistance, and Alternative Path Activity in Plant Mitochondria. Plant Physiol. 1982 Oct;70(4):959-964.

Cyanide inhibited all substrates equally with the exception of malate plus glutamate; in this case, inhibition of O (2) uptake was more severe due to an effect of cyanide on aspartate aminotransferase.
1(0,0,0,1) Details
8097234 Erecinska M, Pleasure D, Nelson D, Nissim I, Yudkoff M: Cerebral aspartate utilization: near-equilibrium relationships in aspartate aminotransferase reaction. J Neurochem. 1993 May;60(5):1696-706.

Rotenone substantially decreased the rate of transamination.
1(0,0,0,1) Details
9178956 Bender AS, Woodbury DM, White HS: The rapid L- and D-aspartate uptake in cultured astrocytes. . Neurochem Res. 1997 Jun;22(6):721-6.


Metabolic energy inhibitors, rotenone and iodoacetate very potently inhibited the L- and D-aspartate uptake processes, indicating that the transport process is an active one.
0(0,0,0,0) Details