Protein Information

Name STAT3
Synonyms APRF; Acute phase response factor; STAT 3; STAT3; Signal transducer and activator of transcription 3; signal transducer and activator of transcription 3 (acute phase response factor); signal transducer and activator of transcription 3 isoform 1; Acute phase response factors…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
20224768 Sarafian TA, Montes C, Imura T, Qi J, Coppola G, Geschwind DH, Sofroniew MV: Disruption of astrocyte STAT3 signaling decreases mitochondrial function and increases oxidative stress in vitro. PLoS One. 2010 Mar 10;5(3):e9532.

Many of the differences observed in STAT3-CKO astrocytes were distinctly altered by exposure to rotenone, suggesting a role for complex I of the mitochondrial electron transport chain.
12(0,0,1,7) Details
19781773 Ito S, Oyake T, Murai K, Ishida Y: Deguelin suppresses cell proliferation via the inhibition of survivin expression and STAT3 phosphorylation in HTLV-1-transformed T cells. Leuk Res. 2010 Mar;34(3):352-7. Epub 2009 Sep 24.

4(0,0,0,4) Details
17442543 Tan QR, Wang XZ, Wang CY, Liu XJ, Chen YC, Wang HH, Zhang RG, Zhen XC, Tong Y, Zhang ZJ: Differential effects of classical and atypical antipsychotic drugs on rotenone-induced neurotoxicity in PC12 cells. Eur Neuropsychopharmacol. 2007 Dec;17(12):768-73. Epub 2007 Apr 17.

We also determined whether there were differential effects of RIP and HAL on the expression of brain-derived neurotrophic factor (BDNF), signal transducers and activators of transcription-3 (STAT-3), and the immediate early gene c-fos, as well as intracellular levels of calcium.
1(0,0,0,1) Details