Protein Information

Name angiopoietin 1
Synonyms AGP1; AGP1; Ang1; AGPT; ANG 1; ANGPT 1; ANGPT1; Angiopoietin 1 precursor…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
16778190 Kim YM, Kim KE, Koh GY, Ho YS, Lee KJ: Hydrogen peroxide produced by angiopoietin-1 mediates angiogenesis. Cancer Res. 2006 Jun 15;66(12):6167-74.

We found that human umbilical vein endothelial cells treated with Ang1 produce ROS transiently, which was suppressed by NADPH oxidase inhibitor, diphenylene-iodonium chloride, and rotenone.
38(0,1,1,8) Details
10854229 Mandriota SJ, Pyke C, Di Sanza C, Quinodoz P, Pittet B, Pepper MS: Hypoxia-inducible angiopoietin-2 expression is mimicked by iodonium compounds and occurs in the rat brain and skin in response to systemic hypoxia and tissue ischemia. Am J Pathol. 2000 Jun;156(6):2077-89.

Ang-1, the major physiological activator of Tie-2, promotes blood vessel maturation and stability.
Neither Ang-2 or VEGF was increased by cyanide or rotenone, suggesting that failure in mitochondrial electron transport is not involved in the oxygen-sensing system that controls their expression.
3(0,0,0,3) Details