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Driscoll KE, Howard BW, Carter JM, Janssen YM, Mossman BT, Isfort RJ: Mitochondrial-derived oxidants and quartz activation of chemokine gene expression. Adv Exp Med Biol. 2001;500:489-96.
Macrophage inflammatory protein 2 (MIP-2) is a chemotactic cytokine which mediates neutrophil recruitment in the lung and other tissues.
Rotenone treatment of RLE-6TN cells attenuated hydrogen peroxide production, NFkappaB activation and MIP-2 gene expression induced by quartz indicating that mitochondria-derived oxidants were contributing to these responses. |
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