| Name | interferon gamma |
|---|---|
| Synonyms | IFG; IFI; IFN gamma; IFNG; IFNgamma; Immune interferon; Interferon gamma; Interferon gamma precursor… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19635391 | Monroe RK, Halvorsen SW: Environmental toxicants inhibit neuronal Jak kinase by mitochondrial disruption. Neurotoxicology. 2009 Jul;30(4):589-98. Epub 2009 Apr 1. Exposure of BE (2)-C cells to the heavy metals CdCl (2) and HgCl (2) and to the mitochondrial complex I inhibitor rotenone inhibited interleukin-6, interferon-gamma and ciliary neurotrophic factor-mediated Jak/STAT signaling, reduced Jak1 and Jak2 auto-phosphorylation and induced Jak nitration. |
81(1,1,1,1) | Details |
| 15748169 | Kaur N, Lu B, Monroe RK, Ward SM, Halvorsen SW: Inducers of oxidative stress block ciliary neurotrophic factor activation of Jak/STAT signaling in neurons. J Neurochem. 2005 Mar;92(6):1521-30. Treatment of neurons with H (2) O (2) and rotenone also inhibited interferon-gamma-mediated activation of Jak/STAT1. |
81(1,1,1,1) | Details |
| 18481258 | Wu F, Tyml K, Wilson JX: iNOS expression requires oxidase-dependent redox signaling in microvascular endothelial cells. J Cell Physiol. 2008 Oct;217(1):207-14. Redox regulation of inducible synthase (iNOS) expression was investigated in lipopolysaccharide and interferon-gamma (LPS + IFNgamma)-stimulated microvascular endothelial cells from mouse skeletal muscle. Unstimulated endothelial cells produced reactive species (ROS) sensitive to inhibition of oxidase (apocynin and DPI), mitochondrial respiration (rotenone) and NOS (L-NAME). |
4(0,0,0,4) | Details |
| 8445326 | Tucker SD, Auzenne EJ, Sivaramakrishnan MR: Inhibition of tumor cell mitochondrial respiration by macrophage cytotoxic mediators distinct from interferon-gamma. J Leukoc Biol. 1993 Feb;53(2):138-43. |
3(0,0,0,3) | Details |
| 17376993 | Mount MP, Lira A, Grimes D, Smith PD, Faucher S, Slack R, Anisman H, Hayley S, Park DS: Involvement of interferon-gamma in microglial-mediated loss of dopaminergic neurons. J Neurosci. 2007 Mar 21;27(12):3328-37. To examine more mechanistically the role of IFN-gamma in microglial activation, we evaluated the interactions between microglia and dopaminergic neurons in an in vitro mixed microglia/midbrain neuron rotenone-induced death paradigm. |
2(0,0,0,2) | Details |
| 7532384 | Duval DL, Sieg DJ, Billings RE: Regulation of hepatic synthase by reactive intermediates and Arch Biochem Biophys. 1995 Feb 1;316(2):699-706. synthase (NOS) induction by tumor necrosis factor-alpha (TNF alpha) is synergized by interferon-gamma, and both NOS activity and gene expression are maximal by 10 h and maintained through 24 h. NOS induction in TNF alpha-treated cells is reduced by rotenone, a mitochondrial complex 1 inhibitor. |
1(0,0,0,1) | Details |
| 8529105 | Barton CH, Whitehead SH, Blackwell JM: Nramp transfection transfers Ity/Lsh/Bcg-related pleiotropic effects on macrophage activation: influence on oxidative burst and pathways. Mol Med. 1995 Mar;1(3):267-79. RESULTS: Expression of the transgene correlated with three Lshr-associated lipopolysaccharide/interferon-gamma-regulated macrophage activation phenotypes: respiratory burst, release, and uptake of The mitochondrial electron transport inhibitors, rotenone and thenoyltrifluoroacetone, inhibited respiratory burst, and rotenone suppressed flux, implying that mitochondrial-derived radicals are important mediators in Nramp-regulated signal transduction pathways. |
1(0,0,0,1) | Details |
| 17562359 | Staines DR: Is Parkinson's disease an autoimmune disorder of endogenous vasoactive neuropeptides?. Med Hypotheses. 2007;69(6):1208-11. Epub 2007 Jun 11. PACAP specifically protects against the neurotoxicity induced by rotenone as well as protecting against oxidative stress-induced apoptosis. Involvement of the Th1 directed cytokine interferon-gamma has been demonstrated and Th2 directed cytokines such as IL-10 protect against inflammation-mediated degeneration of dopaminergic neurons in the SN. |
1(0,0,0,1) | Details |
| 17765224 | Yang D, Elner SG, Bian ZM, Till GO, Petty HR, Elner VM: Pro-inflammatory cytokines increase reactive species through mitochondria and oxidase in cultured RPE cells. Exp Eye Res. 2007 Oct;85(4):462-72. Epub 2007 Jun 27. We investigated if pro-inflammatory cytokines, tumor necrosis factor (TNF)-alpha, interleukin-1 beta (IL-1 beta), and interferon-gamma (IFN-gamma), induce ROS in human retinal pigment epithelial (RPE) cells. Thenoyltrifluoroacetone (TTFA), an inhibitor of mitochondrial respiratory chain, blocked TNF-alpha- and IFN-gamma-, but not IL-1 beta-induced ROS, whereas other two mitochondrial respiratory chain inhibitors, rotenone and antimycin A, had no effect. |
1(0,0,0,1) | Details |
| 17196160 | Yamamoto F, Ohgari Y, Yamaki N, Kitajima S, Shimokawa O, Matsui H, Taketani S: The role of in (ALA)-induced photosensitivity of cancerous cells. Biochem Biophys Res Commun. 2007 Feb 16;353(3):541-6. Epub 2006 Dec 22. When mouse macrophage-like RAW264.7 cells were cultured with lipopolysaccharide and interferon-gamma, the expression of NOS2 was induced. The levels of mitochondrial ferrochelatase and rotenone-sensitive NADH dehydrogenase in the NOS2-induced cells decreased. |
1(0,0,0,1) | Details |
| 8700134 | Duval DL, Miller DR, Collier J, Billings RE: Characterization of hepatic synthase: identification as the cytokine-inducible form primarily regulated by oxidants. Mol Pharmacol. 1996 Aug;50(2):277-84. Cytokine treatment increased nuclear factor-kappa B binding, and the addition of antioxidants or rotenone inhibited cytokine activation. Induction of hepatic synthase (NOS) by tumor necrosis factor-alpha (TNF alpha), interleukin-1 beta (IL-1 beta), interferon-gamma (IFN gamma), interleukin-6 (IL-6), and lipopolysaccharide was assessed as activity and immunoreactive protein. |
1(0,0,0,1) | Details |
| 11710721 | Sambo P, Baroni SS, Luchetti M, Paroncini P, Dusi S, Orlandini G, Gabrielli A: Oxidative stress in scleroderma: maintenance of scleroderma fibroblast phenotype by the constitutive up-regulation of reactive species generation through the oxidase complex pathway. Arthritis Rheum. 2001 Nov;44(11):2653-64. This suppression was not seen with rotenone, a mitochondrial oxidase inhibitor, or allopurinol, a xanthine oxidase inhibitor. |
0(0,0,0,0) | Details |
| 11239497 | Guo Q, Tirosh O, Packer L: Inhibitory effect of and its positively charged amide analogue on production in RAW 264.7 macrophages. Biochem Pharmacol. 2001 Mar 1;61(5):547-54. Furthermore, in the presence of 2.5 or 25 mM the inhibitory effects of R (+) LA and R (+) LA-plus on NO production were decreased markedly, while they showed more potent inhibitory effects in the presence of 2 microM rotenone or 5 microg/mL of antimycin A, inhibitors of mitochondrial complex I and complex III, respectively. |
0(0,0,0,0) | Details |