| Name | integrin |
|---|---|
| Synonyms | Alpha 11 precursor; HsT18964; ITGA11; Integrin; Integrin alpha 11; Integrin alpha 11 precursor; MSTP018; HsT18964s… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17395008 | Del Carlo M, Schwartz D, Erickson EA, Loeser RF: Endogenous production of reactive species is required for stimulation of human articular chondrocyte matrix metalloproteinase production by fibronectin fragments. Free Radic Biol Med. 2007 May 1;42(9):1350-8. Epub 2007 Jan 24. Cultured cells were stimulated with 25 microg/ml of the alpha5beta1 integrin-binding 110-kDa fibronectin fragment (FN-f) in the presence and absence of various antioxidants including Mn (III) tetrakis (4- (MnTBAP). Preincubation of chondrocytes with rotenone, an inhibitor of the mitochondrial electron transport chain, or nordihydroguaiaretic acid (NDGA), a selective 5-lipoxygenase inhibitor, partially prevented FN-f-stimulated MMP-13 production and decreased MAP kinase and NF-kappaB phosphorylation. |
1(0,0,0,1) | Details |
| 15170659 | Morazzani M, de Carvalho DD, Kovacic H, Smida-Rezgui S, Briand C, Penel C: Monolayer versus aggregate balance in survival process for EGF-induced apoptosis in A431 carcinoma cells: Implication of ROS-P38 MAPK-integrin alpha2beta1 pathway. Int J Cancer. 2004 Jul 20;110(6):788-99. EGF-induced dose-dependent ROS production was inhibited by the oxidase inhibitor, diphenylene iodonium (DPI), in these cells while rotenone was ineffective. |
4(0,0,0,4) | Details |
| 16510472 | Ali MH, Mungai PT, Schumacker PT: Stretch-induced phosphorylation of focal adhesion kinase in endothelial cells: role of mitochondrial oxidants. Am J Physiol Lung Cell Mol Physiol. 2006 Jul;291(1):L38-45. Epub 2006 Mar 1. Mechanical stretch activates a number of signaling pathways in endothelial cells, and it elicits a variety of functional responses including increases in the phosphorylation of focal adhesion kinase (FAK), a nonreceptor kinase involved in integrin-mediated signal transduction. The mitochondrial inhibitors diphenylene iodonium (5 microM) or rotenone (2 microM) attenuated this increase, whereas L-nitroarginine (100 microM), allopurinol (100 microM), or apocynin (30 microM) had no effect. |
1(0,0,0,1) | Details |