Protein Information

Name epidermal growth factor
Synonyms EGF; Epidermal growth factor; Pro epidermal growth factor; Pro epidermal growth factor precursor; URG; Urogastrone; epidermal growth factor (beta urogastrone); Epidermal growth factors…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
1528854 Kato Y, Sato H, Ichikawa M, Suzuki H, Sawada Y, Hanano M, Fuwa T, Sugiyama Y: Existence of two pathways for the endocytosis of epidermal growth factor by rat liver: phenylarsine oxide-sensitive and -insensitive pathways. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8507-11.

However, when we lowered the cellular ATP content with rotenone, the cell-surface binding and internalization of EGF were comparable with the control levels.
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8379942 Soler C, Soley M: Rapid and delayed effects of epidermal growth factor on gluconeogenesis. Biochem J. 1993 Sep 15;294 ( Pt 3):865-72.

All of these rapid effects required the presence of extracellular calcium and disappeared in the presence of rotenone, suggesting that this rapid effect of EGF on gluconeogenesis is secondary to the stimulation of mitochondrial respiration.
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8579111 Bour ES, Ward LK, Cornman GA, Isom HC: Tumor necrosis factor-alpha-induced apoptosis in hepatocytes in long-term culture. Am J Pathol. 1996 Feb;148(2):485-95.


We previously described the use of a chemically defined medium supplemented with epidermal growth factor and dimethylsulfoxide to maintain rat hepatocytes in a highly differentiated state for more than 30 days (long-term culture).
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