| Name | insulin like growth factor I |
|---|---|
| Synonyms | IBP1; MGF; IBP1; IGF 1; IGF IA; IGF IB; IGF1; IGFI… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9834970 | Rowlands JC, Casida JE: oxidoreductase inhibitors block induction of ornithine decarboxylase activity in MCF-7 human breast cancer cells. Pharmacol Toxicol. 1998 Nov;83(5):214-9. Rotenone inhibits ornithine decarboxylase activity equally well as induced by TPA, insulin-like growth factor I and 17 beta- |
81(1,1,1,1) | Details |
| 19874289 | Avila-Gomez IC, Velez-Pardo C, Jimenez-Del-Rio M: Effects of insulin-like growth factor-1 on rotenone-induced apoptosis in human lymphocyte cells. Basic Clin Pharmacol Toxicol. 2010 Jan;106(1):53-61. Epub 2009 Oct 28. Since insulin-like growth factor-1 (IGF-1) interferes with a cell's apoptotic machinery when subjected to several stressful conditions, it is demonstrated here for the first time that IGF-1 effectively protects lymphocytes against rotenone through PI-3K/Akt activation, down-regulation of p53 and maintenance of mitochondrial membrane potential independently of ROS generation. |
32(0,1,1,2) | Details |
| 19735655 | Quesada A, Micevych P, Handforth A: C-terminal mechano growth factor protects neurons: a novel peptide that induces heme oxygenase-1. Exp Neurol. 2009 Dec;220(2):255-66. Epub 2009 Sep 6. We show that a short 24-amino acid C-terminal peptide of MGF (MGF24) upregulates heme oxygenase-1 (HO-1) expression and protects SH-SY5Y cells against apoptosis and cell loss induced by three DA cell-specific neurotoxins: (6-OHDA), 1-methyl-4-phenylpyridinium (MPP (+)), and rotenone. |
2(0,0,0,2) | Details |