| Name | PK1 |
|---|---|
| Synonyms | Black mamba toxin related protein; PRK 1; PRK1; EG VEGF; EGVEGF; Endocrine gland derived vascular endothelial growth factor; Mambakine; PK1… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9361019 | Pombo CM, Tsujita T, Kyriakis JM, Bonventre JV, Force T: Activation of the Ste20-like oxidant stress response kinase-1 during the initial stages of chemical anoxia-induced necrotic cell death. J Biol Chem. 1997 Nov 14;272(46):29372-9. We report that SOK-1 is markedly activated as early as 20 min after chemical anoxia induced by exposure of Madin-Darby canine kidney or LLC-PK1 renal tubular epithelial cells to 2-deoxyglucose (2-DG) and any one of three inhibitors of the electron transport chain, (CN), rotenone, or antimycin A. |
32(0,1,1,2) | Details |
| 2019985 | Takayama A, Okazaki Y, Fukuda K, Takano M, Inui K, Hori R: Transport of cyclosporin A in kidney epithelial cell line (LLC-PK1). . J Pharmacol Exp Ther. 1991 Apr;257(1):200-4. The initial uptake was saturable and was inhibited by cyclosporin A analogs, cyclosporin C and D and by but not by metabolic inhibitors such as 2,4-dinitrophenol and rotenone. |
4(0,0,0,4) | Details |
| 3091808 | Saito H, Inui K, Hori R: Mechanisms of gentamicin transport in kidney epithelial cell line (LLC-PK1). J Pharmacol Exp Ther. 1986 Sep;238(3):1071-6. Gentamicin uptake was inhibited by metabolic inhibitors such as rotenone and 2,4-dinitrophenol, and was inhibited competitively in the presence of other aminoglycosides. |
4(0,0,0,4) | Details |
| 19088429 | Oliver R 3rd, Friday E, Turturro F, Welbourne T: Troglitazone induced cytosolic acidification via extracellular signal-response kinase activation and mitochondrial depolarization: complex I pumping regulates ammoniagenesis in proximal tubule-like LLC-PK1 cells. Cell Physiol Biochem. 2008;22(5-6):475-86. Epub 2008 Dec 9. TRO-enhanced acid production was correlated with mitochondrial membrane potential and rotenone and 5-(N-ethyl-N-isopropyl) amiloride, were employed to test specifically the role of Complex I pumping. |
2(0,0,0,2) | Details |
| 8023909 | Doctor RB, Bacallao R, Mandel LJ: Method for recovering ATP content and mitochondrial function after chemical anoxia in renal cell cultures. Am J Physiol. 1994 Jun;266(6 Pt 1):C1803-11. Glycolysis was inhibited by removing all glycolytic substrates, and mitochondrial respiration was inhibited with rotenone, a site I inhibitor of the electron transport chain. Employing Madin-Darby canine kidney and LLC-PK1 cell lines, this protocol caused the immediate and complete recovery of mitochondrial respiration and, by 60 min, the complete recovery of cellular ATP levels. |
1(0,0,0,1) | Details |
| 9453005 | Nath KA, Grande JP, Croatt AJ, Likely S, Hebbel RP, Enright H: Intracellular targets in heme protein-induced renal injury. Kidney Int. 1998 Jan;53(1):100-11. At concentrations of 50 microM, heme induced approximately 20% positivity in MDCK cells but none in LLC-PK1 cells by the TUNEL technique. With either / or /rotenone, state 3 and uncoupled respirations were decreased at three hours, and at 24 hours, such decrements were quite pronounced; in the presence of / state 2 respiration was also depressed at 24 hours, while with /rotenone state 2 was increased. |
1(0,0,0,1) | Details |