Protein Information

Name bradykinin
Synonyms Alpha 2 thiol proteinase inhibitor; BDK; Bradykinin; KNG; KNG 1; KNG1; Kininogen; Kininogen 1 precursor…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
1646057 Richards JM, Gibson IF, Martin W: Effects of hypoxia and metabolic inhibitors on production of prostacyclin and endothelium-derived relaxing factor by pig aortic endothelial cells. Br J Pharmacol. 1991 Jan;102(1):203-9.

The content of adenosine triphosphate (ATP) and basal and bradykinin-stimulated production of prostacyclin and endothelium-derived relaxing factor (EDRF) was measured in primary cultures of porcine aortic endothelial cells under normoxic (14.4% O2) and hypoxic (2.8% O2) conditions, and following treatment with rotenone and 2-deoxy glucose, which inhibit oxidative and glycolytic metabolism, respectively. 2.
85(1,1,1,5) Details
9732284 Landolfi B, Curci S, Debellis L, Pozzan T, Hofer AM: Ca2+ homeostasis in the agonist-sensitive internal store: functional interactions between mitochondria and the ER measured In situ in intact cells. J Cell Biol. 1998 Sep 7;142(5):1235-43.

Treatment with mitochondrial inhibitors (FCCP, antimycin A, oligomycin, and rotenone) dramatically prolonged the refilling of stores after release with bradykinin.
32(0,1,1,2) Details
2997289 Brazy PC, Trellis DR, Klotman PE: Bradykinin stimulation of oxidative metabolism in renal cortical tubules from rabbit. J Clin Invest. 1985 Nov;76(5):1812-8.

6(0,0,0,6) Details
17827868 Zhao Y, Migita K, Sato C, Usune S, Iwamoto T, Katsuragi T: Endoplasmic reticulum is a key organella in bradykinin-triggered ATP release from cultured smooth muscle cells. J Pharmacol Sci. 2007 Sep;105(1):57-65. Epub 2007 Sep 8.

5(0,0,0,5) Details
19213944 Larsen BT, Bubolz AH, Mendoza SA, Pritchard KA Jr, Gutterman DD: Bradykinin-induced dilation of human coronary arterioles requires NADPH oxidase-derived reactive oxygen species. Arterioscler Thromb Vasc Biol. 2009 May;29(5):739-45. Epub 2009 Feb 12.

In HCAs or HCAECs incubated with dihydroethidium and dichlorodihydrofluorescein, BK induced superoxide and H2O2 formation, which was inhibited by gp91ds-tat or apocynin but not by gp91scram-tat or rotenone.
2(0,0,0,2) Details
18052679 Sall Diallo A, Sarr M, Mostefai HA, Carusio N, Pricci M, Andriantsitohaina R: Cognac polyphenolic compounds increase bradykinin-induced nitric oxide production in endothelial cells. Physiol Res. 2008;57(6):885-92. Epub 2007 Nov 30.

Moreover, CPC plus BK response was greater after inhibition of either NADPH oxidase by apocynin or xanthine oxidase by allopurinol but it was not affected by rotenone.
1(0,0,0,1) Details
16733097 Isik S, Castillo J, Blochl A, Csoregi E, Schuhmann W: Simultaneous detection of L-glutamate and nitric oxide from adherently growing cells at known distance using disk shaped dual electrodes. Bioelectrochemistry. 2007 Jan;70(1):173-9. Epub 2006 Apr 7.


Ca (2+)-channel inhibitors for testing Ca (2+)-dependence of the release of NO and glutamate, rotenone for inducing oxidative stress and glutamate antagonists for analysing glutamate release.
0(0,0,0,0) Details