| Name | PPAR gamma |
|---|---|
| Synonyms | HUMPPARG; PAX8/PPARG fusion gene; NR1C3; PPAR gamma; PPAR gamma2; PPARG; PPARG 1; PPARG 2… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16737744 | Koutsogiannaki S, Evangelinos N, Koliakos G, Kaloyianni M: Cytotoxic mechanisms of Zn2+ and Cd2+ involve Na+/H+ exchanger (NHE) activation by ROS. Aquat Toxicol. 2006 Jul 20;78(4):315-24. Epub 2006 May 1. Our results show a key role of NHE in the signal transduction pathway induced by Zn and Cd in gill cells, with the involvement of ROS, PKC, adrenergic and PPAR-gamma receptors. Incubation of gill cells with the oxidants rotenone, antimycin A and caused a significant increase in pHi (delta pHi 0.830, 0.272 and 0.610, respectively), while in the presence of the anti-oxidant N-acetyl (NAC) a decrease in pHi (delta pHi -0.090) was measured, indicating that change in reactive species (ROS) production by heavy metals affects NHE activity. |
1(0,0,0,1) | Details |
| 15183193 | Atarod EB, Kehrer JP: Dissociation of oxidant production by peroxisome proliferator-activated receptor ligands from cell death in human cell lines. Free Radic Biol Med. 2004 Jul 1;37(1):36-47. Rotenone and antimycin A prevented Wy14643- but not ciglitazone-induced oxidant production. The current study examined the ability of Wy14643, a fibrate and PPARalpha agonist, and ciglitazone, a thiazolidinedione and PPARgamma agonist, to induce apoptosis as well as the production of oxidants in human Jurkat T cells that express all PPAR isoforms. |
1(0,0,0,1) | Details |
| 20064719 | Geldenhuys WJ, Funk MO, Barnes KF, Carroll RT: Structure-based design of a thiazolidinedione which targets the mitochondrial protein mitoNEET. Bioorg Med Chem Lett. 2010 Feb 1;20(3):819-23. Epub 2010 Jan 4. To investigate the ability of NL-1 to block rotenone initiated free radicals from complex I, we found it was able to protect the human neuronal cell line SH-SY5Y against rotenone induced cell death. Several PPAR-gamma agonists containing a thiazolidinedione moiety (referred to as glitazones) have been proposed to be neuroprotective and appear to alter mitochondrial function. |
1(0,0,0,1) | Details |
| 18624765 | Zhang H, Jia H, Liu J, Ao N, Yan B, Shen W, Wang X, Li X, Luo C, Liu J: Combined R- and exerts efficient preventative effects in a cellular model of Parkinson's disease. J Cell Mol Med. 2008 Jun 20. The present study examined the preventative effects of two mitochondrial antioxidant/nutrients, R- (LA) and (ALC), in a chronic rotenone-induced cellular model of PD. We also found that pretreatment with combined LA and ALC increased mitochondrial biogenesis and decreased production of reactive species through the upregulation of the peroxisome proliferator-activated receptor-gamma coactivator 1alpha as a possible underlying mechanism. |
1(0,0,0,1) | Details |
| 19772854 | Aronis A, Aharoni-Simon M, Madar Z, Tirosh O: Triacylglycerol-induced impairment in mitochondrial biogenesis and function in J774.2 and mouse peritoneal macrophage foam cells. Arch Biochem Biophys. 2009 Dec;492(1-2):74-81. Epub 2009 Sep 20. Inhibitors of mitochondrial complexes, rotenone (0.1 microM) and myxothiazol (25 nM), protected the viability in TG-loaded macrophages. The exposure to TG caused downregulation of PPARgamma coactivator (PGC)-1alpha and nuclear respiratory factor (NRF)-1. |
1(0,0,0,1) | Details |
| 15131242 | Morioka N, Kumagai K, Morita K, Kitayama S, Dohi T: Nonsteroidal anti-inflammatory drugs potentiate 1-methyl-4-phenylpyridinium (MPP+)-induced cell death by promoting the intracellular accumulation of MPP+ in PC12 cells. J Pharmacol Exp Ther. 2004 Aug;310(2):800-7. Epub 2004 May 6. In contrast, these NSAIDs had no effect on rotenone-induced cell death. |
0(0,0,0,0) | Details |
| 19693701 | Lu RH, Ji H, Chang ZG, Su SS, Yang GS: Mitochondrial development and the influence of its dysfunction during rat adipocyte differentiation. Mol Biol Rep. 2009 Aug 20. The damage to mitochondrial respiratory chain function by rotenone caused significant decrease in gene expressions including mitochondrial MDH and PGC-1beta, and PPARgamma, CAAT/enhancer binding protein alpha (C/EBPalpha) and sterol regulatory element binding protein-1c (SREBP-1c), which are known as transcription factors of differentiation, and differentiation marker gene named fatty acid synthetase. |
31(0,1,1,1) | Details |
| 12187333 | Chen SY, Lu FJ, Gau RJ, Yang ML, Huang TS: 15-Deoxy-delta12,14- induces apoptosis of a thyroid papillary cancer cell line (CG3 cells) through increasing intracellular iron and oxidative stress. Anticancer Drugs. 2002 Aug;13(7):759-65. Treatment of carcinoma cell lines with 15-deoxy-delta12,14- (15d-PGJ2), a natural ligand of the peroxisome proliferator-activated receptor-gamma, has been reported to induce apoptosis and/or inhibit proliferation. Mitochondrial oxidative phosphorylation inhibitors (carbonyl m-chloro-phenylhydrazone, oligomycin, cyclosporin A and rotenone), oxidase inhibitor (diphenyleneiodonium), xanthine oxidase inhibitor (allopurinol) and NO synthase inhibitor (N-monomethyl- did not reduce the generation of ROS. |
1(0,0,0,1) | Details |
| 19861415 | Chowanadisai W, Bauerly KA, Tchaparian E, Wong A, Cortopassi GA, Rucker RB: Pyrroloquinoline stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression. J Biol Chem. 2010 Jan 1;285(1):142-52. Epub 2009 Oct 27. Moreover, PQQ protected cells from mitochondrial inhibition by rotenone, 3-nitropropionic acid, antimycin A, and azide. The induction of this process occurred through the activation of cAMP response element-binding protein (CREB) and peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha), a pathway known to regulate mitochondrial biogenesis. |
1(0,0,0,1) | Details |
| 17951219 | Sharifpanah F, Wartenberg M, Hannig M, Piper HM, Sauer H: Peroxisome proliferator-activated receptor alpha agonists enhance cardiomyogenesis of mouse ES cells by utilization of a reactive species-dependent mechanism. Stem Cells. 2008 Jan;26(1):64-71. Epub 2007 Oct 18. In contrast, the PPARalpha antagonist MK886 decreased cardiomyogenesis, whereas the PPARbeta agonist L-165,041 as well as the PPARgamma agonist GW1929 were without effects. Treatment with PPARalpha, but not PPARbeta, and PPARgamma agonists and MK886, resulted in generation of reactive species (ROS), which was inhibited in the presence of the oxidase inhibitors diphenylen iodonium (DPI) and apocynin and the free radical scavengers and N-(2-mercapto-propionyl)- (NMPG), whereas the mitochondrial complex I inhibitor rotenone was without effects. |
1(0,0,0,1) | Details |
| 15545227 | Scatena R, Martorana GE, Bottoni P, Giardina B: Mitochondrial dysfunction by synthetic ligands of peroxisome proliferator activated receptors (PPARs). IUBMB Life. 2004 Aug;56(8):477-82. As a matter of fact, some synthetic PPAR-ligands have been already employed in pharmacotherapy: PPAR-alpha ligands, such as fibrates, are used in hyperlipidemias and thiazolidinediones, mainly PPAR-gamma ligands, are employed as insulin sensitizers. A re-evaluation of the biological activities of PPAR synthetic ligands, in particular of the mitochondrial dysfunction based on a rotenone-like Complex I partial inhibition and of its consequent metabolic adaptations, seems to explain some of the pathophysiologic aspects of PPARs allowing a better definition of the therapeutic properties of the so-called PPAR-ligands. |
1(0,0,0,1) | Details |
| 15485993 | Pignatelli M, Sanchez-Rodriguez J, Santos A, Perez-Castillo A: 15-deoxy-Delta-12,14- induces programmed cell death of breast cancer cells by a pleiotropic mechanism. Carcinogenesis. 2005 Jan;26(1):81-92. Epub 2004 Oct 14. Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) has been found to induce cell death in a variety of cells. In contrast, the addition of radical scavengers or rotenone, which prevent 15dPG-J2-induced ROS production, block the loss of cell viability induced by this prostaglandin. |
3(0,0,0,3) | Details |
| 15729575 | Artwohl M, Furnsinn C, Waldhausl W, Holzenbein T, Rainer G, Freudenthaler A, Roden M, Baumgartner-Parzer SM: Thiazolidinediones inhibit proliferation of microvascular and macrovascular cells by a PPARgamma-independent mechanism. Diabetologia. 2005 Mar;48(3):586-94. Epub 2005 Feb 24. Proliferation inhibition and lactate release were mimicked by rotenone (mitochondrial complex I inhibitor). |
3(0,0,0,3) | Details |