Protein Information

Name calcium channel (protein family or complex)
Synonyms calcium channel

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
9843468 Riou L, Ghezzi C, Mouton O, Mathieu JP, Pasqualini R, Comet M, Fagret D: Cellular uptake mechanisms of 99mTcN-NOET in cardiomyocytes from newborn rats: calcium channel interaction. Circulation. 1998 Dec 8;98(23):2591-7.

The energy dependence of TcN-NOET uptake was investigated after 60 minutes of metabolic inhibition by iodoacetic acid plus rotenone.
2(0,0,0,2) Details
19772851 Laberge RM, Ambadipudi R, Georges E: P-glycoprotein (ABCB1) modulates collateral sensitivity of a multidrug resistant cell line to verapamil. Arch Biochem Biophys. 2009 Nov;491(1-2):53-60. Epub 2009 Sep 20.

However, the over-expression of P-glycoprotein in some tumor cells has been associated with increased sensitivity, or "collateral sensitivity", of multidrug resistant cells to specific drugs, including the calcium channel blocker verapamil.
Moreover, known inhibitors of ETC, rotenone and antimycin A which cause an increase in reactive oxygen species, synergized with verapamil-induced collateral sensitivity leading to increased cell death as determined by MTT cell survival assay.
1(0,0,0,1) Details
19137688 Berezhnov AV, Fedotova EI, Nenov MN, Kokoz IuM, Zinchenko VP, Dynnik VV: [Destabilization of the cytosolic calcium level and cardiomyocyte death in the presence of long-chain fatty acid derivatives]. Biofizika. 2008 Nov-Dec;53(6):1025-32.

In the presence of rotenone and oligomycin the elevation of [Ca2+] i after the addition of acylcarnitines occurs without the lag-period.
This effect is independent on extracellular calcium and L-type calcium channel inhibitors.
1(0,0,0,1) Details
1720333 MacDonald MJ: Stimulation of insulin release from pancreatic islets by quinones. Biosci Rep. 1991 Jun;11(3):165-70.


Inhibitors of mitochondrial respiration (rotenone, antimycin A, FCCP and cyanide) and the calcium channel blocker verapamil, did not inhibit CoQ0-induced insulin release.
0(0,0,0,0) Details