| 11371681 |
Jones K, Hoggard PG, Sales SD, Khoo S, Davey R, Back DJ: Differences in the intracellular accumulation of HIV protease inhibitors in vitro and the effect of active transport. AIDS. 2001 Apr 13;15(6):675-81.
The effect of active transport was investigated using cells expressing P-glycoprotein (CEM (VBL)) and cells expressing multidrug resistance-associated protein 1 (MRP1; CEM (E1000)).
Incubations were also carried out at 4 degrees C and in the presence of 2-deoxyglucose plus rotenone to examine the effect of inhibiting active transport. |
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