| Name | P glycoprotein |
|---|---|
| Synonyms | ABC20; MDR1; ABCB 1; ABCB1; ATP binding cassette sub family B member 1; CD243; CD243 antigen; CLCS… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15796199 | Gyemant N, Tanaka M, Antus S, Hohmann J, Csuka O, Mandoky L, Molnar J: In vitro search for synergy between flavonoids and epirubicin on multidrug-resistant cancer cells. In Vivo. 2005 Mar-Apr;19(2):367-74. Major P-gp-mediated efflux pump modifiers are amorphigenin, rotenone and chrysin, while MRP-mediated efflux pump modifiers are afrormosin, robinin, and |
83(1,1,1,3) | Details |
| 19772851 | Laberge RM, Ambadipudi R, Georges E: P-glycoprotein (ABCB1) modulates collateral sensitivity of a multidrug resistant cell line to Arch Biochem Biophys. 2009 Nov;491(1-2):53-60. Epub 2009 Sep 20. Moreover, known inhibitors of ETC, rotenone and antimycin A which cause an increase in reactive species, synergized with -induced collateral sensitivity leading to increased cell death as determined by MTT cell survival assay. |
3(0,0,0,3) | Details |
| 17604344 | Iwakiri T, Okumura M, Hidaka M, Kumagai Y, Ichihara E, Kawano Y, Arimori K: Inhibition of carrier-mediated uptake of epirubicin reduces cytotoxicity in primary culture of rat hepatocytes. J Appl Toxicol. 2008 Apr;28(3):329-36. Epirubicin, an antineoplastic drug, is considered to be taken up by tumor cells via a common carrier by facilitated diffusion and is then pumped out in an energy-dependent manner because epirubicin is a substrate for P-glycoprotein (P-gp). The uptake of epirubicin at a clinical concentration (7.5 x 10 (-7) M) was significantly reduced at 4 degrees C and significantly inhibited when pretreated with metabolic inhibitors (carbonyl p-trifluoromethoxyphenylhydrazone (FCCP), rotenone and azide) by nearly 25%. |
1(0,0,0,1) | Details |
| 11371681 | Jones K, Hoggard PG, Sales SD, Khoo S, Davey R, Back DJ: Differences in the intracellular accumulation of HIV protease inhibitors in vitro and the effect of active transport. AIDS. 2001 Apr 13;15(6):675-81. The effect of active transport was investigated using cells expressing P-glycoprotein (CEM (VBL)) and cells expressing multidrug resistance-associated protein 1 (MRP1; CEM (E1000)). Incubations were also carried out at 4 degrees C and in the presence of 2-deoxyglucose plus rotenone to examine the effect of inhibiting active transport. |
2(0,0,0,2) | Details |
| 19881252 | Togami K, Chono S, Seki T, Morimoto K: Distribution characteristics of telithromycin, a novel ketolide antimicrobial agent applied for treatment of respiratory infection, in lung epithelial lining fluid and alveolar macrophages. Drug Metab Pharmacokinet. 2009;24(5):411-7. The uptake of TEL by NR8383 was inhibited by rotenone and FCCP, ATP depletors and was temperature-dependent. These data suggest that the high distribution of TEL to AMs is due to the sustained distribution to ELF via MDR1 as well as the high uptake by AMs themselves via active transport mechanisms. |
1(0,0,0,1) | Details |
| 18998398 | de Ines C, Argandona VH, Rovirosa J, San-Martin A, Diaz-Marrero AR, Cueto M, Gonzalez-Coloma A: Cytotoxic activity of halogenated monoterpenes from Plocamium cartilagineum. Z Naturforsch C. 2004 May-Jun;59(5-6):339-44. Interestingly, the effect of compound 3 was specific and irreversible to human colon adenocarcinoma SW480 cells, which overexpress the transmembrane P-glycoprotein often related to chemoresistance. Furthermore, analysis of cellular extracts after incubation with the test compounds and rotenone (positive uptake control) demonstrated the intracellular accumulation of 1, 2, 3, and 5. |
1(0,0,0,1) | Details |
| 16703323 | Muller C, Gross D, Sarli V, Gartner M, Giannis A, Bernhardt G, Buschauer A: Inhibitors of kinesin Eg5: antiproliferative activity of monastrol analogues against human glioblastoma cells. Cancer Chemother Pharmacol. 2007 Feb;59(2):157-64. Epub 2006 May 16. Due to the necessity of overcoming the blood-brain barrier in the treatment of brain tumours, we investigated if the new monastrol analogues are modulators or substrates of the p-glycoprotein (p-gp) 170 by a flow cytometric calcein-AM efflux assay. |
1(0,0,0,1) | Details |
| 12562089 | Gonzalez-Coloma A, Guadano A, de Ines C, Martinez-Diaz R, Cortes D: Selective action of acetogenin mitochondrial complex I inhibitors. . Z Naturforsch C. 2002 Nov-Dec;57(11-12):1028-34. Five annonaceous acetogenins, rolliniastatin-1 [structure: see text], rolliniastatin-2 [structure: see text], laherradurin [structure: see text], squamocin [structure: see text], annonacin [structure: see text], and rotenone as a reference, differing in their oxidase inhibition activity, have been evaluated for antifeedant, insecticidal, trypanocidal and cytotoxic effects on insect, mammalian and tumor cells. All the test compounds were toxic to Leptinotarsa decemlineata, demonstrated selective cytotoxicity to insect Sf9 cells and a panel of tumor cell lines with the multidrug-resistant SW480 (P-glycoprotein+, Pgp+) being the most sensitive one. |
1(0,0,0,1) | Details |
| 16781454 | Kachadourian R, Day BJ: -induced depletion: potential implications for cancer treatment. Free Radic Biol Med. 2006 Jul 1;41(1):65-76. Epub 2006 Mar 31. In general, these flavonoids were more effective than three classical substrates of multidrug resistance protein 1 (MK-571, indomethacin, and Prototypic flavonoids (2',5'-DHC and chrysin) were subsequently tested for their abilities to potentiate the toxicities of prooxidants (etoposide, rotenone, and |
1(0,0,0,1) | Details |
| 9186779 | Richardson DR: Mobilization of iron from neoplastic cells by some iron chelators is an energy-dependent process. Biochim Biophys Acta. 1997 May 16;1320(1):45-57. Interestingly, the metabolic inhibitors, 2,4-dinitrophenol, oligomycin, rotenone, and azide, markedly decreased 59Fe mobilization mediated by PIH, but had either no effect or much less effect on 59Fe release by 311. Considering that an ATP-dependent process was involved in 59Fe release by PIH, further studies examined 4 widely used inhibitors of the multi-drug efflux pump P-glycoprotein (P-gp). |
1(0,0,0,1) | Details |
| 8609886 | Shu LL, Houghton PJ: Separation of resistance to antitumor diarylsulfonylurea agents from collateral sensitivity to mitochondrial toxins. Mol Pharmacol. 1996 Apr;49(4):595-601. Compared with parental GC3/c1 human colon adenocarcinoma cells, which are diarylsulfonylurea (DSU)-sensitive cells, the DSU-resistant clone LYC5 demonstrates 4.2-, 12.8-, and 5.3- fold increase in sensitivity to the mitochondrial toxins rotenone, antimycin, and oligomycin, respectively. |
0(0,0,0,0) | Details |