| Name | EDRF |
|---|---|
| Synonyms | AHSP; Alpha hemoglobin stabilizing protein; EDRF; ERAF; Erythroid associated factor; Erythroid differentiation related factor; Alpha hemoglobin stabilizing proteins; Erythroid associated factors… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3502252 | Griffith TM, Edwards DH, Henderson AH: Unstimulated release of endothelium derived relaxing factor is independent of mitochondrial generation. Cardiovasc Res. 1987 Aug;21(8):565-8. Since haemoglobin inhibits and the phosphodiesterase inhibitor, MB22948, amplifies endothelium dependent relaxation they were used to provide evidence of basal activity of endothelium derived relaxing factor (EDRF). |
2(0,0,0,2) | Details |
| 8156634 | Close LA, Bowman PS, Paul RJ: Reoxygenation-induced relaxation of coronary arteries. Circ Res. 1994 May;74(5):870-81. The reoxygenation relaxation was, however, sensitive to very low levels of and was inhibited by and rotenone, suggesting an involvement of mitochondrial metabolism. Mechanisms underlying endothelium-dependent effects of include the sensitivity of the /endothelium-derived relaxing factor (EDRF), peroxide, and eicosanoid pathways. |
2(0,0,0,2) | Details |
| 2001289 | Rodman DM, Mallet J, McMurtry IF: Difference in effect of inhibitors of energy metabolism on endothelium-dependent relaxation of rat pulmonary artery and aorta. Am J Respir Cell Mol Biol. 1991 Mar;4(3):237-42. Previous studies have suggested that systemic artery endothelial cell production of the nitrovasodilator endothelium-derived relaxing factor (EDRF) is dependent upon oxidative energy production. In aortic rings, 0.1 microM rotenone and 0.1 microM antimycin A, and, to a lesser extent, 50 mM 2-deoxyglucose, inhibited endothelium-dependent relaxation to and |
2(0,0,0,2) | Details |
| 1646055 | Weir CJ, Gibson IF, Martin W: Effects of metabolic inhibitors on endothelium-dependent and endothelium-independent vasodilatation of rat and rabbit aorta. Br J Pharmacol. 1991 Jan;102(1):162-6. These data suggest that in rabbit and in rat aorta, rotenone inhibits -induced relaxation by inhibiting EDRF production, and by depressing smooth muscle sensitivity to EDRF, respectively. |
85(1,1,1,5) | Details |
| 1646057 | Richards JM, Gibson IF, Martin W: Effects of hypoxia and metabolic inhibitors on production of and endothelium-derived relaxing factor by pig aortic endothelial cells. Br J Pharmacol. 1991 Jan;102(1):203-9. The content of (ATP) and basal and bradykinin-stimulated production of and endothelium-derived relaxing factor (EDRF) was measured in primary cultures of porcine aortic endothelial cells under normoxic (14.4% O2) and hypoxic (2.8% O2) conditions, and following treatment with rotenone and 2-deoxy which inhibit oxidative and glycolytic metabolism, respectively. 2. |
34(0,1,1,4) | Details |
| 9152848 | Cappelli-Bigazzi M, Battaglia C, Pannain S, Chiariello M, Ambrosio G: Role of oxidative metabolism on endothelium-dependent vascular relaxation of isolated vessels. J Mol Cell Cardiol. 1997 Mar;29(3):871-9. However, the chemical identity of endothelium-derived relaxing (EDRF) and the mechanisms underlying its synthesis and release remain unclear. In contrast, inhibition of oxidative metabolism with either 1 mM amytal or 5 microM rotenone markedly impaired relaxation to |
3(0,0,0,3) | Details |