Protein Information

Name glucose transporter 4
Synonyms GLUT 4; GLUT4; Glucose transporter 4; SLC2A4; Solute carrier family 2 member 4; Glucose transporter 4s; Solute carrier family 2 member 4s

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
11713226 Becker C, Sevilla L, Tomas E, Palacin M, Zorzano A, Fischer Y: The endosomal compartment is an insulin-sensitive recruitment site for GLUT4 and GLUT1 glucose transporters in cardiac myocytes. Endocrinology. 2001 Dec;142(12):5267-76.

Rotenone recruited GLUT4 and GLUT1 to the cell surface from endosomal pool 2 without affecting pool 1.
117(1,2,2,7) Details
11531163 Bergemann C, Loken C, Becker C, Graf B, Hamidizadeh M, Fischer Y: Inhibition of glucose transport by cyclic GMP in cardiomyocytes. Life Sci. 2001 Aug 10;69(12):1391-406.


Confocal laser scanning microscopic studies revealed that cGMP partially prevents the insulin-induced redistribution of the glucose transporter GLUT4 from intracellular stores to the cell surface.
1(0,0,0,1) Details
8447373 Bashan N, Burdett E, Guma A, Sargeant R, Tumiati L, Liu Z, Klip A: Mechanisms of adaptation of glucose transporters to changes in the oxidative chain of muscle and fat cells. Am J Physiol. 1993 Feb;264(2 Pt 1):C430-40.


To understand the underlying cellular mechanisms involved in this adaptive response, the effects of an uncoupler of oxidative phosphorylation, 2,4-dinitrophenol (DNP), and of an inhibitor of the electron transport chain, rotenone, were compared with the effect of hypoxia in L6 muscle cells and 3T3-L1 adipocytes.
0(0,0,0,0) Details
7841183 Wheeler TJ, Fell RD, Hauck MA: Translocation of two glucose transporters in heart: effects of rotenone, uncouplers, workload, palmitate, insulin and anoxia. Biochim Biophys Acta. 1994 Dec 30;1196(2):191-200.

Our previous studies on the acute regulation of glucose transport in perfused rat hearts were extended to explore further the mechanism of regulation by anoxia; to test the effects of palmitate, a transport inhibitor; and to compare the translocation of two glucose transporter isoforms (GLUT1 and GLUT4).
2(0,0,0,2) Details
17471172 Xi L, Qian Z, Xu G, Zhou C, Sun S: Crocetin attenuates palmitate-induced insulin insensitivity and disordered tumor necrosis factor-alpha and adiponectin expression in rat adipocytes. Br J Pharmacol. 2007 Jul;151(5):610-7. Epub 2007 Apr 30.

EXPERIMENTAL APPROACH: We used palmitate to induce insulin resistance in freshly isolated rat adipocytes, and observed the effect of crocetin, N-acetylcysteine, diphenyleneiodonium, rotenone and oxypurinol.
Levels of glucose transporter 4, TNF-alpha and adiponectin were evaluated by immunoblot analysis, and levels of mRNA for TNF-alpha and adiponectin by reverse transcription-polymerase chain reaction analysis.
1(0,0,0,1) Details