Protein Information

Name immunoglobulin (protein family or complex)
Synonyms Immunoglobulin; Immunoglobulins

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
16365155 Suzuki Y, Yoshimaru T, Inoue T, Ra C: Mitochondrial Ca2+ flux is a critical determinant of the Ca2+ dependence of mast cell degranulation. J Leukoc Biol. 2006 Mar;79(3):508-18. Epub 2005 Dec 19.

In the presence of extracellular Ca2+, mitochondrial metabolic inhibitors, including rotenone, antimycin A, and the protonophore carbonyl cyanide p-trifluoromethoxyphenylhydrazone (FCCP), significantly reduced degranulation induced by immunoglobulin E (IgE) antigen or by thapsigargin, as measured by beta-hexosaminidase release.
81(1,1,1,1) Details
6626158 Weisbecker U, Ibbotson GE, Livesey G, Williams KE: The fate of homologous 125I-labelled immunoglobulin G within rat visceral yolk sacs incubated in vitro. Biochem J. 1983 Sep 15;214(3):815-22.

When rotenone (10 microM) is also present in the incubation medium, the rate of digestion of IgG is inhibited to the same extent as the rate of pinocytosis of 125I-labelled polyvinylpyrrolidone.
2(0,0,0,2) Details
16157303 Nutku E, Hudson SA, Bochner BS: Mechanism of Siglec-8-induced human eosinophil apoptosis: role of caspases and mitochondrial injury. Biochem Biophys Res Commun. 2005 Oct 28;336(3):918-24.

Sialic acid binding immunoglobulin like lectin (Siglec)-8 crosslinking with specific antibodies causes human eosinophil apoptosis.
Rotenone and antimycin, inhibitors of mitochondrial respiratory chain components, completely inhibited apoptosis.
1(0,0,0,1) Details
2158476 Meier B, Radeke HH, Selle S, Raspe HH, Sies H, Resch K, Habermehl GG: Human fibroblasts release reactive oxygen species in response to treatment with synovial fluids from patients suffering from arthritis. Free Radic Res Commun. 1990;8(3):149-60.


Radical production and light emission were not altered either by xanthine or allopurinol, nor by azide, cyanide or rotenone.
0(0,0,0,0) Details