| Name | neurotrophic factors |
|---|---|
| Synonyms | ARTN; Artemin; Artemin precursor; EVN; Enovin; NBN; Neublastin; Neuroblastin… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20003314 | Falk T, Zhang S, Sherman SJ: Vascular endothelial growth factor B (VEGF-B) is up-regulated and exogenous VEGF-B is neuroprotective in a culture model of Parkinson's disease. Mol Neurodegener. 2009 Dec 10;4:49. Neurotrophic factors have shown preclinical promise, but the choice of an appropriate growth factor as well as the delivery has proven difficult. In this study, we used a rotenone rat midbrain culture model to identify genes that are changed after addition of the neurotoxin. (1) We challenged rat midbrain cultures with rotenone (20 nM), a pesticide that has been shown to be toxic for dopaminergic neurons and that has been a well-characterized model of PD. |
1(0,0,0,1) | Details |
| 17555550 | Hirata Y, Kiuchi K: Rapid down-regulation of Ret following exposure of dopaminergic neurons to neurotoxins. J Neurochem. 2007 Sep;102(5):1606-13. Epub 2007 Jun 7. The survival and functional maintenance of vertebrate neurons depends on the availability of specific neurotrophic factors. Down-regulation of Ret was also observed in -producing PC12 cells undergoing apoptosis induced by rotenone, another toxic substance for dopaminergic neurons, while other cellular components were not affected. |
1(0,0,0,1) | Details |
| 19558709 | Ming M, Li X, Fan X, Yang D, Li L, Chen S, Gu Q, Le W: Retinal pigment epithelial cells secrete neurotrophic factors and synthesize possible contribution to therapeutic effects of RPE cell transplantation in Parkinson's disease. J Transl Med. 2009 Jun 28;7:53. METHODS: We evaluated the protective effects of conditioned medium (CM) from cultured RPE cells on the DAergic cells against (6-OHDA)- and rotenone-induced neurotoxicity and determined the levels of glial cell derived neurotrophic factor (GDNF) and brain derived neurotrophic factor (BDNF) released by RPE cells. |
1(0,0,0,1) | Details |
| 16887804 | Jiang Q, Yan Z, Feng J: Neurotrophic factors stabilize microtubules and protect against rotenone toxicity on dopaminergic neurons. J Biol Chem. 2006 Sep 29;281(39):29391-400. Epub 2006 Aug 3. Moreover, other neurotrophic factors such as brain-derived neurotrophic factor and glia cell line-derived neurotrophic factor also reduced rotenone- or colchicine-induced microtubule depolymerization and death of TH (+) through a MEK-dependent mechanism. |
68(0,2,3,3) | Details |
| 17029596 | Hirata Y, Meguro T, Kiuchi K: Differential effect of nerve growth factor on dopaminergic neurotoxin-induced apoptosis. J Neurochem. 2006 Oct;99(2):416-25. In this paper, we focused on the differences between rotenone and as toxins, and characterized the influence of neurotrophic factors on toxin-induced apoptosis in PC12 cells. |
7(0,0,1,2) | Details |