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Sauer H, Dagdanova A, Hescheler J, Wartenberg M: Redox-regulation of intrinsic prion expression in multicellular prostate tumor spheroids. Free Radic Biol Med. 1999 Dec;27(11-12):1276-83.
The cellular function of the intrinsic prion protein (PrPc) remains largely unknown.
ROS generation was mediated by the mitochondrial respiratory chain and a NADPH oxidaselike enzyme, because carbonylcyanide-m-chlorophenylhydrazone (CCCP), rotenone, and diphenylene iodonium chloride (DPI) significantly reduced ROS levels. |
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