| 18614807 |
He Y, Ge J, Tombran-Tink J: Mitochondrial defects and dysfunction in calcium regulation in glaucomatous trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2008 Nov;49(11):4912-22. Epub 2008 Jul 9.
METHODS: Primary cultures of TM cells from POAG (GTM) and age-matched, nondiseased (NTM) eyes, obtained from postmortem donors eyes by standard surgical trabeculectomy, were treated with the following calcium regulators: the mitochondrial respiratory chain I inhibitor rotenone (ROT); the mitochondrial permeability transition pore (MPTP) inhibitors cyclosporine (Cys) and aristolochic acid (ArA); the Ca (2+) chelators BAPTA/AM or EDTA; the mitochondrial Ca (2+) uniporter inhibitor ruthenium red (RR); the Ca (2+)/Na (+) exchanger inhibitor trifluoperazine; and the inositol 1,4,5-triphosphate receptor type 3 (IP3R) inhibitors 2-aminoethoxydiphenyl borane (2-APB) and xestospongin C (Xe-C). |
33(0,1,1,3) |
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