| Name | CoQ 1 |
|---|---|
| Synonyms | COQ 1; transprenyltransferase; COQ1; DPS 1; DPS1; Decaprenyl pyrophosphate synthetase subunit 1; Decaprenyl diphosphate synthase subunit 1; PDSS 1… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17601793 | Merker MP, Audi SH, Lindemer BJ, Krenz GS, Bongard RD: Role of mitochondrial electron transport complex I in reduction by intact pulmonary arterial endothelial cells and the effect of hyperoxia. Am J Physiol Lung Cell Mol Physiol. 2007 Sep;293(3):L809-19. Epub 2007 Jun 29. The mitochondrial electron transport complex I inhibitor rotenone decreased the CoQ (1) reduction rate by 85% in the normoxic cells and 44% in the hyperoxia-exposed cells. |
36(0,1,1,6) | Details |
| 17706244 | de Wit LE, Spruijt L, Schoonderwoerd GC, de Coo IF, Smeets HJ, Scholte HR, Sluiter W: A simplified and reliable assay for complex I in human blood lymphocytes. . J Immunol Methods. 2007 Sep 30;326(1-2):76-82. Epub 2007 Aug 1. The results of the present study show that permeabilization of human blood lymphocytes in the presence of protease inhibitors by three cycles of freeze-thawing enables reproducible detection of the rotenone-sensitive complex I activity. To that end, the water-soluble (10) analogue CoQ (1) and a relatively high concentration of blood lymphocytes were combined in small quartz cuvettes so that the amount of blood needed for this assay remained low. |
1(0,0,0,1) | Details |
| 16641458 | Biagini GA, Viriyavejakul P, O'neill PM, Bray PG, Ward SA: Functional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondria. Antimicrob Agents Chemother. 2006 May;50(5):1841-51. PfNDH2 was shown to actively oxidize in the presence of electron acceptors CoQ (1) and decylubiquinone with an apparent K (m) for of approximately 17 and 5 muM, respectively. The inhibitory profile of PfNDH2 revealed that the enzyme activity was insensitive to rotenone, consistent with recent genomic data indicating the absence of the canonical NADH:dehydrogenase enzyme. |
1(0,0,0,1) | Details |
| 18703762 | Audi SH, Merker MP, Krenz GS, Ahuja T, Roerig DL, Bongard RD: redox metabolism during passage through the rat pulmonary circulation and the effect of hyperoxia. J Appl Physiol. 2008 Oct;105(4):1114-26. Epub 2008 Aug 14. In normoxic lungs, CoQ (1) H (2) efflux rates when CoQ (1) was infused decreased by 58 and 33% in the presence of rotenone (mitochondrial complex I inhibitor) and dicumarol [NAD (P) H-quinone oxidoreductase 1 (NQO1) inhibitor], respectively. |
36(0,1,1,6) | Details |
| 19059197 | Fato R, Bergamini C, Bortolus M, Maniero AL, Leoni S, Ohnishi T, Lenaz G: Differential effects of mitochondrial Complex I inhibitors on production of reactive species. Biochim Biophys Acta. 2009 May;1787(5):384-92. Epub 2008 Nov 14. Our results indicate that different Complex I inhibitors can be grouped into two classes: Class A inhibitors (Rotenone, Piericidin A and Rolliniastatin 1 and 2) increase ROS production; Class B inhibitors (Stigmatellin, Mucidin, and (2)) prevent ROS production also in the presence of Class A inhibitors. This behaviour relates the prooxidant CoQ (1) activity to a hydrophilic electron escape site. |
1(0,0,0,1) | Details |