Protein Information

Name TGFbeta
Synonyms CED; DPD 1; DPD1; TGF beta; TGF beta 1; TGFB; TGFB 1; TGFB1…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
17635749 Ho C, Lee PH, Huang WJ, Hsu YC, Lin CL, Wang JY: Methylglyoxal-induced fibronectin gene expression through Ras-mediated NADPH oxidase activation in renal mesangial cells. Nephrology. 2007 Aug;12(4):348-56.

METHODS: Rat kidney mesangial cells with or without pretreatment with inhibitors, including superoxide dismutase, catalase, L-NAME, diphenylene iodonium, rotenone, allopurinol, PD98059, SB203580 and SP600125 were cultured in medium containing 100 microM MGO.
Scavenging O (2) (-) reversed transforming growth factor beta 1 (TGF-beta1) and fibronectin mRNA level.
1(0,0,0,1) Details
16120427 Blanco FJ, Lopez-Armada MJ, Maneiro E: Mitochondrial dysfunction in osteoarthritis. . Mitochondrion. 2004 Sep;4(5-6):715-28. Epub 2004 Oct 1.

Inhibition of MRC with antimycin prevents the normal ability of TGFbeta to increase excretion of Pi, thereby worsening deposition of pathologic HA crystals.
Inhibition of complex I with rotenone increases the expression and synthesis of Bcl-2 and Cox-2, both effects are similar effects to produced by IL-1 in human chondrocytes.
1(0,0,0,1) Details