| Name | heat shock protein 60 |
|---|---|
| Synonyms | 60 kDa chaperonin; CPN60; Chaperonin; Chaperonin 60 homolog; GROEL; GroEL homolog; HSP 60; HSP60… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17855661 | Hsu YC, Lee HC, Ping YH, Liu TY, Lui WY, Chi CW: Mitochondria are an essential mediator of /cyclic 3',5'-monophosphate blocking of depletion induced cytotoxicity in human HepG2 cells. Mol Cancer Res. 2007 Sep;5(9):923-32. Furthermore, we found that rotenone and antimycin A (mitochondria complex I and III inhibitors, respectively) blocked SNP cytoprotection against depletion-induced cytotoxicity. Moreover, depletion decreased the expression of various mitochondrial proteins, including cytochrome c, complex I (NADH dehydrogenase), complex III (cytochrome c reductase), and heat shock protein 60; these depletion-induced effects were blocked by SNP. |
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| 16678137 | Ho HK, Jia Y, Coe KJ, Gao Q, Doneanu CE, Hu Z, Bammler TK, Beyer RP, Fausto N, Bruschi SA, Nelson SD: Cytosolic heat shock proteins and heme oxygenase-1 are preferentially induced in response to specific and localized intramitochondrial damage by tetrafluoroethylcysteine. Biochem Pharmacol. 2006 Jun 28;72(1):80-90. Epub 2006 Mar 29. Previously, S-(1,1,2,2-tetrafluoroethyl)- (TFEC) was shown to mediate cytotoxicity by covalently modifying a well-defined group of intramitochondrial proteins including aconitase, alpha-ketoglutarate dehydrogenase (alphaKGDH) subunits, heat shock protein 60 (HSP60) and mitochondrial HSP70 (mtHSP70). Results of these studies revealed a HSP response that was significantly stronger than other well-characterized hepatotoxicants including diquat and rotenone. |
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