| 7724472 |
Terasaki T, Mizuguchi H, Itoho C, Tamai I, Lemaire M, Tsuji A: Hepatic uptake of octreotide, a long-acting somatostatin analogue, via a bile acid transport system. Pharm Res. 1995 Jan;12(1):12-7.
An energy requirement was demonstrated for [14C] octreotide uptake since metabolic inhibitors (DNP, rotenone, antimycin and NaCN) significantly reduced the initial uptake rate. [14C] octreotide uptake was also significantly inhibited by ouabain. [14C] octreotide uptake was reduced in the absence of Na+ in the uptake medium. [14C] octreotide uptake was significantly inhibited by bile acids, iodipamide, d-tubocurarine, whereas it was not inhibited by bilirubin, TEMA and insulin. |
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