Protein Information

Name novel proteins
Synonyms DDX59; DEAD (Asp Glu Ala Asp) box polypeptide 59; DEAD box polypeptide 59; Novel protein; RP11 92G12.2; ZNHIT 5; ZNHIT5; DEAD (Asp Glu Ala Asp) box polypeptide 59s…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
17705834 Jin J, Davis J, Zhu D, Kashima DT, Leroueil M, Pan C, Montine KS, Zhang J: Identification of novel proteins affected by rotenone in mitochondria of dopaminergic cells. BMC Neurosci. 2007 Aug 16;8:67.
6(0,0,1,1) Details
16854843 Jin J, Li GJ, Davis J, Zhu D, Wang Y, Pan C, Zhang J: Identification of novel proteins associated with both alpha-synuclein and DJ-1. Mol Cell Proteomics. 2007 May;6(5):845-59. Epub 2006 Jul 18.

In the current study, we analyzed proteins associated with alpha-synuclein and/or DJ-1 with a robust proteomics technique called stable isotope labeling by amino acids in cell culture (SILAC) in dopaminergic MES cells exposed to rotenone versus controls.
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19409963 Caudle WM, Kitsou E, Li J, Bradner J, Zhang J: A role for a novel protein, nucleolin, in Parkinson's disease. Neurosci Lett. 2009 Jul 31;459(1):11-5. Epub 2009 May 4.

Thus, the identification and biological evaluation of novel proteins involved in these pathways is critical to providing a more comprehensive understanding of PD pathogenesis.
Furthermore, manipulation of nucleolin in an in vitro model of PD resulted in significant alterations in the generation of oxidative stress as well as proteasomal inhibition following rotenone exposure.
1(0,0,0,1) Details