| Name | nNOS |
|---|---|
| Synonyms | Constitutive NOS; NOS1; IHPS 1; IHPS1; N NOS; NC NOS; NOS; NOS type I… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 14642398 | Gil J, Almeida S, Oliveira CR, Rego AC: Cytosolic and mitochondrial ROS in staurosporine-induced retinal cell apoptosis. Free Radic Biol Med. 2003 Dec 1;35(11):1500-14. Endogenous sources of ROS production were investigated by testing the effect of the following inhibitors: 7-nitroindazole (7-NI), a specific inhibitor of the neuronal isoform of synthase (nNOS); arachidonyl trifluoromethyl ketone (AACOCF (3)), a phospholipase A (2) (PLA (2)) inhibitor; allopurinol, a xanthine oxidase inhibitor; and the mitochondrial inhibitors rotenone and oligomycin. |
31(0,1,1,1) | Details |
| 16085056 | Bae SY, Xu Q, Hutchinson D, Colton CA: Y+ and y+ transporters in neuronal cells expressing tyrosine hydroxylase. Biochim Biophys Acta. 2005 Aug 15;1745(1):65-73. Epub 2005 Feb 9. Neurons that express nNOS require intracellular to generate (NO). Short term exposure to the oxidizing agents, rotenone and Angeli's salt, but not FeSO4, increases transport. |
1(0,0,0,1) | Details |
| 9694040 | Cutillas B, Espejo M, Ambrosio S: 7-Nitroindazole prevents depletion caused by low concentrations of MPP+ in rat striatal slices. Neurochem Int. 1998 Jul;33(1):35-40. This protection was reproduced with other less specific NOS-inhibitors, such as nitro- and nitro- methylester. 7-nitroindazole did not protect against the depletion caused by the non-specific mitochondrial chain blocker rotenone. The inhibition of nNOS may protect against loss at early stages of a neurodegenerative process, and it could then be considered in the treatment or prevention of neurodegenerative human processes such as Parkinson's disease. |
1(0,0,0,1) | Details |
| 19103678 | Dedkova EN, Blatter LA: Characteristics and function of cardiac mitochondrial synthase. J Physiol. 2009 Feb 15;587(Pt 4):851-72. Epub 2008 Dec 22. Collapsing the mitochondrial membrane potential with the protonophore FCCP or blocking the mitochondrial Ca (2+) uniporter with Ru360 as well as blocking the respiratory chain with rotenone or antimycin A in combination with oligomycin inhibited mitochondrial NO production. |
0(0,0,0,0) | Details |