| Name | survivin |
|---|---|
| Synonyms | API 4; API4; Apoptosis inhibitor 4; Apoptosis inhibitor survivin; BIRC 5; BIRC5; Baculoviral IAP repeat containing protein 5; Baculoviral IAP repeat containing protein 5 isoform 1… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18089792 | Jin Q, Feng L, Behrens C, Bekele BN, Wistuba II, Hong WK, Lee HY: Implication of AMP-activated protein kinase and Akt-regulated survivin in lung cancer chemopreventive activities of deguelin. Cancer Res. 2007 Dec 15;67(24):11630-9. |
8(0,0,0,8) | Details |
| 18593368 | Yi T, Li H, Wang X, Wu Z: Enhancement radiosensitization of breast cancer cells by deguelin. Cancer Biother Radiopharm. 2008 Jun;23(3):355-62. OBJECTIVE: Radiation can activate the phosphatidylinositol 3-kinase/Akt pathway and cannot downregulate survivin expression in breast cancer cells. |
4(0,0,0,4) | Details |
| 19781773 | Ito S, Oyake T, Murai K, Ishida Y: Deguelin suppresses cell proliferation via the inhibition of survivin expression and STAT3 phosphorylation in HTLV-1-transformed T cells. Leuk Res. 2010 Mar;34(3):352-7. Epub 2009 Sep 24. |
4(0,0,0,4) | Details |
| 17035597 | Peng XH, Karna P, O'Regan RM, Liu X, Naithani R, Moriarty RM, Wood WC, Lee HY, Yang L: Down-regulation of inhibitor of apoptosis proteins by deguelin selectively induces apoptosis in breast cancer cells. Mol Pharmacol. 2007 Jan;71(1):101-11. Epub 2006 Oct 11. Increasing evidence shows that the inhibitor of apoptosis (IAP) proteins survivin and XIAP are highly expressed in tumor cells but are absent or have very low levels of expression in normal adult tissues. |
2(0,0,0,2) | Details |
| 19455392 | Chen Y, Wu Q, Cui GH, Chen YQ, Li R: Deguelin blocks cells survival signal pathways and induces apoptosis of HL-60 cells in vitro. Int J Hematol. 2009 Jun;89(5):618-23. Epub 2009 May 20. To investigate the anti-cancer effects and molecular mechanism of deguelin on the human leukemia HL-60 cells, to explore the expression and clinical significance of p-AKT, survivin and Bcl-2 in leukemia cell line HL-60 cell. |
2(0,0,0,2) | Details |
| 16952909 | Dell'Eva R, Ambrosini C, Minghelli S, Noonan DM, Albini A, Ferrari N: The Akt inhibitor deguelin, is an angiopreventive agent also acting on the NF-kappaB pathway. Carcinogenesis. 2007 Feb;28(2):404-13. Epub 2006 Sep 4. Growth arrest is associated with induction of p21 and p53 and decreased survivin levels. |
1(0,0,0,1) | Details |