| Name | GTPase |
|---|---|
| Synonyms | RAC3; RAC3; Ras related C3 botulinum substrate 3; Ras related C3 botulinum toxin substrate 3; p21 Rac3; Ras related C3 botulinum substrate 3s; Ras related C3 botulinum toxin substrate 3s; p21 Rac3s… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16357365 | Brueckl C, Kaestle S, Kerem A, Habazettl H, Krombach F, Kuppe H, Kuebler WM: Hyperoxia-induced reactive species formation in pulmonary capillary endothelial cells in situ. Am J Respir Cell Mol Biol. 2006 Apr;34(4):453-63. Epub 2005 Dec 15. To determine mechanisms and time course of EC activation in normobaric hyperoxia, we measured endothelial concentration of reactive species (ROS) and cytosolic ([Ca (2+)](i)) by in situ imaging of 2',7'-dichlorofluorescein (DCF) and fura 2 fluorescence, respectively, and translocation of the small GTPase Rac1 by immunofluorescence in isolated perfused rat lungs. ROS and [Ca (2+)](i) responses were blocked by the mitochondrial complex I inhibitor rotenone, whereas inhibitors of NAD (P) H oxidase and the intracellular Ca (2+) chelator BAPTA predominantly attenuated the late phase of the hyperoxia-induced DCF fluorescence increase after > 30 min. |
1(0,0,0,1) | Details |
| 18480073 | Sanchez M, Gastaldi L, Remedi M, Caceres A, Landa C: Rotenone-induced toxicity is mediated by Rho-GTPases in hippocampal neurons. Toxicol Sci. 2008 Aug;104(2):352-61. Epub 2008 May 13. Taken together, our data suggest that at least some of the effects of rotenone are associated with an inhibition of actin dynamics through modifications of Rho-GTPase activity. |
81(1,1,1,1) | Details |
| 18257932 | Wang D, Tang B, Zhao G, Pan Q, Xia K, Bodmer R, Zhang Z: Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons. Mol Neurodegener. 2008 Feb 8;3:3. However, dLRRK mutant flies were selectively sensitive to peroxide induced stress but not to paraquat, rotenone and beta-mercaptoethanol induced stresses. LRRK2 encodes a large putative serine/threonine kinase with GTPase activity. |
1(0,0,0,1) | Details |
| 10973919 | Deshpande SS, Angkeow P, Huang J, Ozaki M, Irani K: Rac1 inhibits TNF-alpha-induced endothelial cell apoptosis: dual regulation by reactive species. FASEB J. 2000 Sep;14(12):1705-14. Rotenone, a mitochondrial electron transport chain inhibitor, suppressed TNF-induced mitochondrial ROS production, proteolytic cleavage of procaspase-3, and apoptosis. |
0(0,0,0,0) | Details |