| Name | ornithine decarboxylase |
|---|---|
| Synonyms | ODC; ODC 1; ODC 2; ODC1; ODC1 protein; ODC2; ODCP; Ornithine decarboxylase… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9834970 | Rowlands JC, Casida JE: oxidoreductase inhibitors block induction of ornithine decarboxylase activity in MCF-7 human breast cancer cells. Pharmacol Toxicol. 1998 Nov;83(5):214-9. Rotenone is the classical inhibitor of oxidoreductase and its analogue deguelin is a potent inhibitor of 12-O-tetradecanoylphorbol 13- (TPA)-induced ornithine decarboxylase mRNA steady state level and enzyme activity in mouse 308 cells (Gerhauser et al. 1995). |
164(2,2,2,4) | Details |
| 9520374 | Fang N, Casida JE: Anticancer action of cube insecticide: correlation for rotenoid constituents between inhibition of NADH:ubiquinone oxidoreductase and induced ornithine decarboxylase activities. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3380-4. The toxic action of rotenone is attributed to inhibition of NADH:ubiquinone oxidoreductase activity and the purported cancer chemopreventive effect of deguelin analogs has been associated with inhibition of phorbol ester-induced ornithine decarboxylase (ODC) activity. |
32(0,1,1,2) | Details |
| 962864 | Murphy BJ, Brosnan ME: Subcellular localization of ornithine decarboxylase in liver of control and growth-hormone-treated rats. Biochem J. 1976 Jul 1;157(1):33-9. |
5(0,0,0,5) | Details |
| 9270009 | Gerhauser C, Lee SK, Kosmeder JW, Moriarty RM, Hamel E, Mehta RG, Moon RC, Pezzuto JM: Regulation of ornithine decarboxylase induction by deguelin, a natural product cancer chemopreventive agent. Cancer Res. 1997 Aug 15;57(16):3429-35. These results suggest that antimicrotubule effects, as mediated by rotenone, for example, are not responsible for inhibitory activity facilitated by deguelin. |
2(0,0,0,2) | Details |
| 7585044 | Gerhauser C, Mar W, Lee SK, Suh N, Luo Y, Kosmeder J, Luyengi L, Fong HH, Kinghorn AD, Moriarty RM, et al.: Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylase. Nat Med. 1995 Mar;1(3):260-6. |
2(0,0,0,2) | Details |
| 10552508 | Fang N, Casida JE: Cube resin insecticide: identification and biological activity of 29 rotenoid constituents. J Agric Food Chem. 1999 May;47(5):2130-6. The four major active ingredients are rotenone, deguelin, rotenolone, and tephrosin, totaling 77 wt %. Assays of the 29 rotenoids as inhibitors of NADH:ubiquinone oxidoreductase activity (primary target for toxicity) and phorbol ester-induced ornithine decarboxylase activity (indicator of cancer chemopreventive action) and for cytotoxicity establish similar structure-activity relationships in each system and the importance of the overall molecular conformation and the E-ring substituents. |
1(0,0,0,1) | Details |
| 15192326 | Hail N Jr, Lotan R: Apoptosis induction by the natural product cancer chemopreventive agent deguelin is mediated through the inhibition of mitochondrial bioenergetics. Apoptosis. 2004 Jul;9(4):437-47. However, it has been suggested that this agent reduces ornithine decarboxylase activity, and perhaps the activity of other signaling intermediates associated with tumorigenesis, by inhibiting mitochondrial bioenergetics. |
1(0,0,0,1) | Details |
| 11007319 | Levillain O, Diaz JJ, Reymond I, Soulet D: metabolism along the female mouse nephron: localization of ornithine decarboxylase and ornithine aminotransferase. Pflugers Arch. 2000 Sep;440(5):761-9. Gabaculine, a suicide inhibitor of OAT, and rotenone sharply decreased the production of 14CO2 from [1-14C] |
1(0,0,0,1) | Details |
| 553076 | Grillo MA, Bedino S, Testore G: Catabolism of in chicken liver. . Ital J Biochem. 1979 Jan-Feb;28(1):11-9. Rotenone blocks decarboxylation suggesting that this occurs through the pathway leads to glutamic semialdehyde leads to leads to alpha-ketoglutarate, which in turn is decarboxylated. Insulin promotes a marked increase of cytosol ornithine decarboxylase activity, but has little effect on decarboxylation by the particulate cellular fraction. |
1(0,0,0,1) | Details |
| 16300973 | Bal-Price A, Gartlon J, Brown GC: stimulates PC12 cell proliferation via and inhibits at higher concentrations mainly via energy depletion. Nitric Oxide. 2006 May;14(3):238-46. Epub 2005 Nov 21. Cytostatic concentrations of DETA/NO strongly inhibited respiration of PC12 cells, and specific respiratory inhibitors (rotenone, myxothiazol, or azide) caused complete cytostasis. |
0(0,0,0,0) | Details |