Protein Information

Name serine protease inhibitors
Synonyms HBVDNAPTP 1; HBVDNAPTP1; SPINK5L3; serine protease inhibitor; serine protease inhibitors

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
9264320 Dong Y, Berners-Price SJ, Thorburn DR, Antalis T, Dickinson J, Hurst T, Qiu L, Khoo SK, Parsons PG: Serine protease inhibition and mitochondrial dysfunction associated with cisplatin resistance in human tumor cell lines: targets for therapy. Biochem Pharmacol. 1997 Jun 1;53(11):1673-82.

Indicators of mitochondrial function were studied in two different cell culture models of cis-diamminedichloroplatinum-II (CDDP) resistance: the intrinsically resistant human ovarian cancer cell line CI-80-13S, and resistant clones (HeLa-S1a and HeLa-S1b) generated by stable expression of the serine protease inhibitor-plasminogen activator inhibitor type-2 (PAI-2), in the human cervical cancer cell line HeLa.
Unlike the HeLa clones, CI-80-13S cells were additionally sensitive to chloramphenicol, 1-methyl-4-phenylpyridinium ion (MPP+), rotenone, thenoyltrifluoroacetone (TTFA), and antimycin A, and showed poor reduction of 1-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT), suggesting a deficiency in NADH dehydrogenase and/or succinate dehydrogenase activities.
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14570380 Samuilov VD, Lagunova EM, Kiselevsky DB, Dzyubinskaya EV, Makarova YV, Gusev MV: Participation of chloroplasts in plant apoptosis. Biosci Rep. 2003 Apr-Jun;23(2-3):103-17.


The light-dependent activation of CN (-)-induced apoptosis of guard cells was suppressed by DCMU, stigmatellin or DNP-INT, by a protein kinase inhibitor staurosporine as well as by cysteine and serine protease inhibitors.
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