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Lopez-Barneo J, Ortega-Saenz P, Piruat JI, Garcia-Fernandez M: Oxygen-sensing by ion channels and mitochondrial function in carotid body glomus cells. Novartis Found Symp. 2006;272:54-64; discussion 64-72
However, rotenone, a complex I blocker, selectively occludes the responsiveness to hypoxia of glomus cells in a dose-dependent manner.
We have also generated a knock-out mouse lacking SDHD, the small membrane-anchoring protein of the succinate dehydrogenase (complex II) of the mitochondrial electron transport chain. |
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