| Name | organic cation transporter |
|---|---|
| Synonyms | HIMTP; Organic cation transporter; Putative UST1 like organic anion transporter; Putative integral membrane transport protein; UST 6; UST6; Putative UST1 like organic anion transporters; Putative integral membrane transport proteins |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18606742 | Okura T, Hattori A, Takano Y, Sato T, Hammarlund-Udenaes M, Terasaki T, Deguchi Y: Involvement of the pyrilamine transporter, a putative organic cation transporter, in blood-brain barrier transport of Drug Metab Dispos. 2008 Oct;36(10):2005-13. Epub 2008 Jul 7. The transport was inhibited by metabolic inhibitors (rotenone and azide) but was insensitive to extracellular and membrane potential for both substrates. |
2(0,0,0,2) | Details |
| 17604344 | Iwakiri T, Okumura M, Hidaka M, Kumagai Y, Ichihara E, Kawano Y, Arimori K: Inhibition of carrier-mediated uptake of epirubicin reduces cytotoxicity in primary culture of rat hepatocytes. J Appl Toxicol. 2008 Apr;28(3):329-36. The uptake of epirubicin at a clinical concentration (7.5 x 10 (-7) M) was significantly reduced at 4 degrees C and significantly inhibited when pretreated with metabolic inhibitors (carbonyl p-trifluoromethoxyphenylhydrazone (FCCP), rotenone and azide) by nearly 25%. Furthermore, an organic anion transporter inhibitor, namely, 4,4'-diisothiocyanato-stilbene-2,2'-disulfonic acid (DIDS); organic anion transport substrates, namely, (PAH), and 17-beta-D- and organic cation transporter inhibitors, namely, and tetraethylammonium significantly reduced the uptake of epirubicin. |
1(0,0,0,1) | Details |