| Name | alpha ketoglutarate dehydrogenase |
|---|---|
| Synonyms | 2 ketoglutarate dehydrogenase deficiency; 2 oxoglutarate dehydrogenase E1 component; AKGDH; Alpha KGD deficiency; Alpha ketoglutarate dehydrogenase; Alpha ketoglutarate dehydrogenase deficiency; E1K; OGDC… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11124972 | Tretter L, Adam-Vizi V: Inhibition of Krebs cycle enzymes by peroxide: A key role of [alpha]-ketoglutarate dehydrogenase in limiting production under oxidative stress. J Neurosci. 2000 Dec 15;20(24):8972-9. BCNU-insensitive decline by H (2) O (2) in the rotenone-induced NAD (P) H fluorescence correlated with inhibition of alpha-ketoglutarate dehydrogenase. |
83(1,1,1,3) | Details |
| 14607783 | Peterside IE, Selak MA, Simmons RA: Impaired oxidative phosphorylation in hepatic mitochondria in growth-retarded rats. Am J Physiol Endocrinol Metab. 2003 Dec;285(6):E1258-66. Rotenone-sensitive -O2 oxidoreductase activity was similar in control and IUGR mitochondria at all ages, showing that the defect responsible for decreased and alpha-ketoglutarate oxidation in IUGR liver precedes the electron transport chain and involves and alpha-ketoglutarate dehydrogenases. |
31(0,1,1,1) | Details |
| 9525878 | Rodriguez-Zavala JS, Moreno-Sanchez R: Modulation of oxidative phosphorylation by Mg2+ in rat heart mitochondria. . J Biol Chem. 1998 Apr 3;273(14):7850-5. The effect of varying the Mg2+ concentration on the dehydrogenase (2-OGDH) activity and the rate of oxidative phosphorylation of rat heart mitochondria was studied. Half-maximal stimulation (K0.5) of ATP synthesis by Mg2+ was obtained with 0.13 +/- 0.02 mM (n = 7) with (+rotenone) and 0.48 +/- 0.13 mM (n = 6) with (2-OG) as substrates. |
3(0,0,0,3) | Details |
| 10386974 | Chinopoulos C, Tretter L, Adam-Vizi V: Depolarization of in situ mitochondria due to peroxide-induced oxidative stress in nerve terminals: inhibition of alpha-ketoglutarate dehydrogenase. J Neurochem. 1999 Jul;73(1):220-8. When complex I of the respiratory chain was inhibited by rotenone (2 microM), delta psi (m) was unaltered, but on subsequent addition of H2O2, delta psi (m) started to decrease and collapsed during incubation with 0.5 mM H2O2 for 12 min. |
2(0,0,0,2) | Details |
| 15356189 | Starkov AA, Fiskum G, Chinopoulos C, Lorenzo BJ, Browne SE, Patel MS, Beal MF: Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive species. J Neurosci. 2004 Sep 8;24(36):7779-88. In the absence of ADP or in the presence of rotenone, H (2) O (2) production rates correlated with the reduction level of mitochondrial with various substrates, with the exception of alpha-ketoglutarate. |
2(0,0,0,2) | Details |
| 19526285 | Mallajosyula JK, Chinta SJ, Rajagopalan S, Nicholls DG, Andersen JK: Metabolic control analysis in a cellular model of elevated MAO-B: relevance to Parkinson's disease. Neurotox Res. 2009 Oct;16(3):186-93. Epub 2009 Mar 5. We previously demonstrated that spare respiratory capacity of the TCA cycle enzyme alpha-ketoglutarate dehydrogenase (KGDH) was completely abolished upon increasing levels of MAO-B activity in a dopaminergic cell model system (Kumar et al., J Biol Chem 278:46432-46439, 2003). |
1(0,0,0,1) | Details |
| 16667685 | Pascal N, Dumas R, Douce R: Comparison of the Kinetic Behavior toward Nucleotides of -Linked Dehydrogenases from Plant Mitochondria. Plant Physiol. 1990 Sep;94(1):189-193. In this article we compare the kinetic behavior toward nucleotides (+), of (+)-malic enzyme, pyruvate dehydrogenase, isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, and glycine decarboxylase extracted from pea (Pisum sativum) leaf and potato (Solanum tuberosum) tuber mitochondria. It is suggested that (+)-linked malic enzyme, when fully activated, is able to raise the matricial level up to the required concentration to fully engage the rotenone-resistant internal NADH-dehydrogenase, whose affinity for is weaker than complex I. |
1(0,0,0,1) | Details |
| 8630091 | McNaught KS, Thull U, Carrupt PA, Altomare C, Cellamare S, Carotti A, Testa B, Jenner P, Marsden CD: Effects of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mitochondrial respiration. Biochem Pharmacol. 1996 Jun 14;51(11):1503-11. Isoquinoline derivatives exert 1-methyl-4-phenylpyridinium (MPP+)-like activity as inhibitors of complex I and alpha-ketoglutarate dehydrogenase activity in rat brain mitochondrial fragments. None of the compounds examined inhibited respiration supported by either + rotenone or tetramethylparaphenylenediamine (TMPD) + |
1(0,0,0,1) | Details |
| 10844979 | Obungu VH, Kiaira JK, Olembo NK, Njogu MR: Pathways of catabolism in procyclic Trypanosoma congolense. Indian J Biochem Biophys. 1999 Oct;36(5):305-11. Studies of respiration on in procyclic Trypanosoma congolense in the presence of rotenone, antimycin, salicylhydroxamic acid and have indicated the presence of NADH dehydrogenase, cytochrome b-c1, cytochrome aa3, trypanosome alternate oxidase and reductase/succinate dehydrogenase pathway that contributes electrons to of the respiratory chain. Phosphoenolpyruvate carboxykinase, pyruvate dehydrogenase, succinate dehydrogenase, (+)-linked malic enzyme, reductase, malate dehydrogenase, and alpha-ketoglutarate dehydrogenase and glycerol kinase on the other hand had specific activities greater than 60 nanomoles/min/mg protein. |
1(0,0,0,1) | Details |
| 16678137 | Ho HK, Jia Y, Coe KJ, Gao Q, Doneanu CE, Hu Z, Bammler TK, Beyer RP, Fausto N, Bruschi SA, Nelson SD: Cytosolic heat shock proteins and heme oxygenase-1 are preferentially induced in response to specific and localized intramitochondrial damage by tetrafluoroethylcysteine. Biochem Pharmacol. 2006 Jun 28;72(1):80-90. Epub 2006 Mar 29. Previously, S-(1,1,2,2-tetrafluoroethyl)- (TFEC) was shown to mediate cytotoxicity by covalently modifying a well-defined group of intramitochondrial proteins including aconitase, alpha-ketoglutarate dehydrogenase (alphaKGDH) subunits, heat shock protein 60 (HSP60) and mitochondrial HSP70 (mtHSP70). Results of these studies revealed a HSP response that was significantly stronger than other well-characterized hepatotoxicants including diquat and rotenone. |
1(0,0,0,1) | Details |
| 8786242 | Xu DP, Wells WW: dependent regeneration of from in rat liver mitochondria. J Bioenerg Biomembr. 1996 Feb;28(1):77-85. Electron transport inhibitors, rotenone and antimycin A, further enhanced the reduction. Pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase reduced to in an and or alpha-ketoglutarate dependent fashion. |
1(0,0,0,1) | Details |
| 8417013 | Zaidan E, Sims NR: Selective reductions in the activity of the pyruvate dehydrogenase complex in mitochondria isolated from brain subregions following forebrain ischemia in rats. J Cereb Blood Flow Metab. 1993 Jan;13(1):98-104. No significant changes were observed in the activity of two other mitochondrial markers, rotenone-sensitive -cytochrome c oxidoreductase and alpha-ketoglutarate dehydrogenase. |
0(0,0,0,0) | Details |
| 16781453 | Fedotcheva NI, Sokolov AP, Kondrashova MN: Nonezymatic formation of in mitochondria under oxidative stress. Free Radic Biol Med. 2006 Jul 1;41(1):56-64. Epub 2006 Mar 13. H (2) O (2) and as an inductor of reactive species (ROS) caused the formation of CO (2) in the presence of azide and the production of and in the presence of rotenone. |
0(0,0,0,0) | Details |
| 10425713 | Obungu VH, Kiaira JK, Njogu RM, Olembo NK: Catabolism of by procyclic culture forms of Trypanosoma congolense. Comp Biochem Physiol B Biochem Mol Biol. 1999 May;123(1):59-65. Rotenone had no effect on the rate of respiration except when the intact cells were first permeabilized by digitonin after which rotenone decreased the rate of respiration by 20-30%. Enzymes involved in the catabolism of with high activities were: proline dehydrogenase, alpha-ketoglutarate dehydrogenase, succinate dehydrogenase, fumarase, -linked malic enzyme, alanine aminotransferase and malate dehydrogenase. |
1(0,0,0,1) | Details |