Protein Information

Name protein kinase B
Synonyms AKT; PKB; Protein kinase B; AKT 1; AKT1; C AKT; Oncogene AKT1; PKB alpha…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
15647265 Connelly L, Madhani M, Hobbs AJ: Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knock-out mice: a pro-inflammatory role for eNOS-derived no in vivo. J Biol Chem. 2005 Mar 18;280(11):10040-6. Epub 2005 Jan 12.


Furthermore, in human umbilical vein endothelial cells, LPS leads to the activation of eNOS through phosphoinositide 3-kinase- and Akt/protein kinase B-dependent enzyme phosphorylation.
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15026413 Hashimoto M, Bar-On P, Ho G, Takenouchi T, Rockenstein E, Crews L, Masliah E: Beta-synuclein regulates Akt activity in neuronal cells. J Biol Chem. 2004 May 28;279(22):23622-9. Epub 2004 Mar 16.

The main objective of the present study was to investigate the potential involvement of the serine threonine kinase Akt (also known as protein kinase B) signaling pathway in the mechanisms of beta-synuclein neuroprotection.
Beta-synuclein transfection resulted in increased Akt activity and conferred protection from the neurotoxic effects of rotenone.
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17634444 Li Y, Chandrakanthan V, Day ML, O'Neill C: Direct evidence for the action of phosphatidylinositol (3,4,5)-trisphosphate-mediated signal transduction in the 2-cell mouse embryo. Biol Reprod. 2007 Nov;77(5):813-21. Epub 2007 Jul 18.


The 2-cell embryo expressed three genes for AKT (Akt 1-3) and two genes for phospholipase C gamma (Plcg1 and Plcg2), and we confirmed the expression of both AKT and phospholipase C gamma 1 by immunolocalization.
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