| Name | mcl 1 |
|---|---|
| Synonyms | Bcl 2 related protein EAT/mcl1; EAT; Induced myeloid leukemia cell differentiation protein Mcl 1; MCL 1; MCL1; MCL1L; MCL1S; Myeloid cell leukemia 1… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17568818 | Geeraerts B, Vanhoecke B, Vanden Berghe W, Philippe J, Offner F, Deforce D: Deguelin inhibits expression of IkappaBalpha protein and induces apoptosis of B-CLL cells in vitro. Leukemia. 2007 Aug;21(8):1610-8. Epub 2007 Jun 14. Exposure of B-CLL cells to deguelin resulted in Bcl2-associated protein (Bax) conformational changes and downregulation of the key survival protein myeloid cell leukemia sequence 1 (Mcl-1), which is associated with response to treatment in B-CLL patients. |
1(0,0,0,1) | Details |
| 18817777 | Kamdar O, Le W, Zhang J, Ghio AJ, Rosen GD, Upadhyay D: Air pollution induces enhanced mitochondrial oxidative stress in cystic fibrosis airway epithelium. FEBS Lett. 2008 Oct 29;582(25-26):3601-6. Epub 2008 Sep 24. Mitochondrial inhibitors (4,4-diisothiocyanatostilbene-2,2'disulfonic acid, rotenone and thenoyltrifluoroacetone) blocked PM-induced generation of reactive species and apoptosis. The anti-apoptotic Bcl-2, Bcl-xl, Mcl-1 and Xiap remained unchanged; however, overexpression of Bcl-xl blocked PM-induced apoptosis. |
1(0,0,0,1) | Details |