| Name | mammalian target of rapamycin |
|---|---|
| Synonyms | FK506 binding protein 12 rapamycin complex associated protein 1; FK506 binding protein 12 rapamycin associated protein 1; FKBP12 rapamycin complex associated protein 1; FKBP12 rapamycin complex associated protein; FRAP; FRAP 1; FRAP 2; FRAP1… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17005863 | Malagelada C, Ryu EJ, Biswas SC, Jackson-Lewis V, Greene LA: RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation. J Neurosci. 2006 Sep 27;26(39):9996-10005. |
2(0,0,0,2) | Details |
| 14695307 | Joubert F, Fales HM, Wen H, Combs CA, Balaban RS: enzyme-dependent fluorescence recovery after photobleaching (ED-FRAP): applications to enzyme and mitochondrial reaction kinetics, in vitro. Biophys J. 2004 Jan;86(1 Pt 1):629-45. Evaluation of regeneration in active mitochondria, in comparison to rotenone-treated preparations, revealed other regulatory elements in addition to matrix and [NAD] that have yet to be fully characterized. |
2(0,0,0,2) | Details |
| 19339632 | Huang S, Zhang A, Ding G, Chen R: -induced mesangial cell proliferation is mediated by EGF receptor transactivation. Am J Physiol Renal Physiol. 2009 Jun;296(6):F1323-33. Epub 2009 Apr 1. Pretreatment with the antioxidant N-acetyl- catalase, SOD, mitochondrial respiratory chain complex I inhibitor rotenone (Rot), oxidase inhibitor apocynin, and DPI significantly inhibited Aldo-stimulated MC proliferation as well as EGFR transactivation. Aldo also increased phosphorylation of PI3K, Akt, the mammalian target of rapamycin (mTOR), and the 70-kDa ribosomal S6 kinase (p70S6K1). |
1(0,0,0,1) | Details |
| 12356861 | Dou Y, Bowen J, Liu Y, Gorovsky MA: Phosphorylation and an ATP-dependent process increase the dynamic exchange of H1 in chromatin. J Cell Biol. 2002 Sep 30;158(7):1161-70. To test this hypothesis, we used FRAP of GFP-tagged H1 to analyze the effects of mutations that either eliminate or mimic phosphorylation on the binding of H1 to chromatin both in vivo and in vitro. |
1(0,0,0,1) | Details |
| 11691993 | Dennis PB, Jaeschke A, Saitoh M, Fowler B, Kozma SC, Thomas G: Mammalian TOR: a homeostatic ATP sensor. Science. 2001 Nov 2;294(5544):1102-5. When nutrient concentrations change, particularly those of essential amino acids, the mammalian Target of Rapamycin (mTOR) functions in regulatory pathways that control ribosome biogenesis and cell growth. |
1(0,0,0,1) | Details |
| 17209049 | Bogush A, Pedrini S, Pelta-Heller J, Chan T, Yang Q, Mao Z, Sluzas E, Gieringer T, Ehrlich ME: AKT and CDK5/p35 mediate brain-derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitro. J Biol Chem. 2007 Mar 9;282(10):7352-9. Epub 2007 Jan 5. We demonstrated that both the PI3K/Akt/mammalian target of rapamycin and the cdk5/p35 signal transduction pathways contribute to the induction of DARPP-32 protein levels by BDNF and that the effects are on both the transcriptional and translational levels. |
1(0,0,0,1) | Details |