Protein Information

Name chloride channel (protein family or complex)
Synonyms chloride channel

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
1652470 Lukacs GL, Nanda A, Rotstein OD, Grinstein S: The chloride channel blocker 5-nitro-2-(3-phenylpropyl-amino) benzoic acid (NPPB) uncouples mitochondria and increases the proton permeability of the plasma membrane in phagocytic cells. FEBS Lett. 1991 Aug 19;288(1-2):17-20.

The stimulatory effect of NPPB on O2 consumption, like that of the classical protonophore CCCP, was prevented by the mitochondrial respiratory chain inhibitors antimycin A, rotenone or cyanide.
2(0,0,0,2) Details
17620322 Dhani SU, Kim Chiaw P, Huan LJ, Bear CE: ATP depletion inhibits the endocytosis of ClC-2. . J Cell Physiol. 2008 Jan;214(1):273-80.


The chloride channel, ClC-2 is expressed ubiquitously and participates in multiple physiological processes.
1(0,0,0,1) Details
17173871 Molchanova SM, Oja SS, Saransaari P: Inhibitory effect of taurine on veratridine-evoked D-[3H] aspartate release from murine corticostriatal slices: involvement of chloride channels and mitochondria. Brain Res. 2007 Jan 26;1130(1):95-102. Epub 2006 Dec 14.


The respiratory chain blocker rotenone or mitochondrial protonophore carbonyl cyanide 3-chlorophenylhydrazone (CCCP) in combination with the mitochondrial ATPase inhibitor oligomycin, which inhibits the mitochondrial Ca2+ uniporter, also reduced the effect of taurine.
0(0,0,0,0) Details