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Press C, Milbrandt J: Nmnat delays axonal degeneration caused by mitochondrial and oxidative stress. J Neurosci. 2008 May 7;28(19):4861-71.
The Wld (s) mutation results in the production of a chimeric protein that contains the full-length coding sequence of nicotinamide mononucleotide adenylyltransferase 1 (Nmnat1), which alone is sufficient for axonal protection in vitro.
To test the effects of increased Nmnat expression on axonal degeneration induced by mitochondrial dysfunction, we examined dorsal root ganglion (DRG) neurons treated with rotenone. |
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