| Name | cathepsin D |
|---|---|
| Synonyms | CATD; CLN10; CPSD; CTSD; Cathepsin D; Cathepsin D precursor; cathepsin D (lysosomal aspartyl peptidase); cathepsin D (lysosomal aspartyl protease)… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 223146 | Hayes LW, Goguen CA, Stevens AL, Magargal WW, Slakey LL: Enzyme activities in endothelial cells and smooth muscle cells from swine aorta. Proc Natl Acad Sci U S A. 1979 Jun;76(6):2532-5. In populations of cultured arterial endothelial and smooth muscle cells grown under the same conditions, we have measured the total activity per cell of 10 enzymes commonly used as "markers" for subcellular organelles: ferricyanide reductase, NADH:cytochrome c reductase (rotenone insensitive). NADPH:cytochrome c reductase, alpha-glucosidase, 5'-nucleotidase, alkaline phosphodiesterase I, cytochrome oxidase, monoamine oxidase, cathepsin D, and N-acetyl-beta-glucosaminidase. |
2(0,0,0,2) | Details |
| 17643412 | Choi JH, Kim DH, Yun IJ, Chang JH, Chun BG, Choi SH: Zaprinast inhibits peroxide-induced lysosomal destabilization and cell death in astrocytes. Eur J Pharmacol. 2007 Oct 1;571(2-3):106-15. Epub 2007 Jul 4. H2O2-induced oxidative cytotoxicity was measured grossly by monitoring lactate dehydrogenase (LDH) release, and was found to be associated with lysosomal acridine orange relocation, lysosomal cathepsin D release into cytosol, and reduced mitochondrial potentials. Zaprinast was found to inhibit -induced lysosomal acridine orange relocation and the induced decrease in mitochondrial potential, but zaprinast had no effect on rotenone-induced mitochondrial collapse, which was not associated with lysosomal destabilization. |
1(0,0,0,1) | Details |