| Name | gp91 phox |
|---|---|
| Synonyms | CGD; CGD91 PHOX; CYBB; Cytochrome B 245 heavy chain; Cytochrome B(558) beta chain; Cytochrome b(558) subunit beta; Cytochrome b 245 beta polypeptide; Cytochrome b558 subunit beta… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12867501 | Gao HM, Liu B, Hong JS: Critical role for microglial oxidase in rotenone-induced degeneration of dopaminergic neurons. J Infect Dis. 2000 Jun;181(6):1885-90. Epub 2000 Jun 5. In this study, using primary mesencephalic cultures from oxidase--null (gp91phox-/-) or wild-type (gp91phox+/+) mice, we demonstrated a critical role for microglial oxidase in mediating microglia-enhanced rotenone neurotoxicity. |
18(0,0,3,3) | Details |
| 16647052 | Muzaffar S, Shukla N, Angelini GD, Jeremy JY: auto-augments formation and upregulates gp91 (phox) expression in porcine pulmonary artery endothelial cells: inhibition by iloprost. J Neurosci. 2005 Oct 5;25(40):9176-84. Rotenone and allopurinol were without effect. |
5(0,0,0,5) | Details |
| 10393927 | Archer SL, Reeve HL, Michelakis E, Puttagunta L, Waite R, Nelson DP, Dinauer MC, Weir EK: O2 sensing is preserved in mice lacking the gp91 phox subunit of oxidase. Eur J Pharmacol. 2006 May 24;538(1-3):108-14. Epub 2006 Mar 28. Inhibitors of oxidase (diphenyleneiodonium) and mitochondrial complex 1 (rotenone) both inhibit PASMC whole-cell K+ current but lack the specificity to identify the O2-sensor pathway. |
2(0,0,0,2) | Details |
| 16762927 | Hidalgo C, Sanchez G, Barrientos G, Aracena-Parks P: A transverse tubule oxidase activity stimulates release from isolated triads via ryanodine receptor type 1 S -glutathionylation. J Biol Chem. 2005 Oct 14;280(41):34966-73. Epub 2005 Jul 17. Immunohistochemical determinations with NOX antibodies showed that the gp91 (phox) membrane subunit and the cytoplasmic regulatory p47 (phox) subunit co-localized in transverse tubules of adult mice fibers with the alpha1s subunit of dihydropyridine receptors. or elicited and peroxide generation by isolated triads; both activities were inhibited by NOX inhibitors but not by rotenone. |
2(0,0,0,2) | Details |
| 16207877 | Abramov AY, Jacobson J, Wientjes F, Hothersall J, Canevari L, Duchen MR: Expression and modulation of an oxidase in mammalian astrocytes. . J Neurosci. 2003 Jul 16;23(15):6181-7. This was independent of mitochondrial ROS production, because it was unaffected by mitochondrial depolarization with rotenone and oligomycin. Responses were absent in transgenic mice lacking gp91phox. |
2(0,0,0,2) | Details |
| 18522491 | Wenzel P, Mollnau H, Oelze M, Schulz E, Wickramanayake JM, Muller J, Schuhmacher S, Hortmann M, Baldus S, Gori T, Brandes RP, Munzel T, Daiber A: First evidence for a crosstalk between mitochondrial and oxidase-derived reactive species in nitroglycerin-triggered vascular dysfunction. Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):7944-9. tolerance was induced by nitroglycerin infusion in male Wistar rats (100 microg/h/4 day) and in C57/Bl6, p47 (phox/) and gp91 (phox/) mice (50 microg/h/4 day). Vice versa, tolerance was attenuated by co-treatment with the respiratory chain complex I inhibitor rotenone (100 microg/h/4 day) or the mitochondrial permeability transition pore blocker cyclosporine A (50 microg/h/4 day). |
1(0,0,0,1) | Details |
| 16686432 | Nurse CA, Buttigieg J, Thompson R, Zhang M, Cutz E: sensing in neuroepithelial and chromaffin cells. Novartis Found Symp. 2006;272:106-14; discussion 114-8 Accordingly, hypoxic sensitivity is lost in NEBs from transgenic mice deficient in the gp91 (phox) subunit of oxidase; it is, however, retained in neonatal AMCs from these transgenic mice. For example, the complex I blocker, rotenone (1 microM), mimics hypoxia in causing K+ channel inhibition and ATP secretion, and occludes hypoxic sensitivity. |
1(0,0,0,1) | Details |
| 10837166 | Kaul P, Biagioli MC, Singh I, Turner RB: Rhinovirus-induced oxidative stress and interleukin-8 elaboration involves p47-phox but is independent of attachment to intercellular adhesion molecule-1 and viral replication. J Biol Chem. 2006 Sep 8;281(36):26473-82. Epub 2006 Jun 8. Treatment of cells with diphenylene iodonium inhibited virus-induced oxidative stress and IL-8 elaboration, but allopurinol, and rotenone had no effect. Studies in cell lines produced from a patient with gp91-phox deficiency revealed normal responses. |
1(0,0,0,1) | Details |
| 16024921 | Yang T, Zhang A, Honeggar M, Kohan DE, Mizel D, Sanders K, Hoidal JR, Briggs JP, Schnermann JB: Hypertonic induction of COX-2 in collecting duct cells by reactive species of mitochondrial origin. 131-40. The increases in ROSs in response to hypertonic treatment were completely blocked by any one of the mitochondrial inhibitors tested, such as rotenone, thenoyltrifluoroacetone, or carbonyl m-chlorophenylhydrazone, associated with remarkable inhibition of COX-2 expression. |
0(0,0,0,0) | Details |
| 19371610 | Mo Y, Wan R, Chien S, Tollerud DJ, Zhang Q: Activation of endothelial cells after exposure to ambient ultrafine particles: the role of oxidase. Antioxid Redox Signal. 2008 Aug;10(8):1435-47. Our results showed that UFPs, at a non-toxic dose, induced reactive species (ROS) generation in mouse pulmonary microvascular endothelial cells (MPMVEC) that was inhibited by pre-treatment with the ROS scavengers or inhibitors, but not with the mitochondrial inhibitor, rotenone. |
0(0,0,0,0) | Details |