Protein Information

Name extracellular superoxide dismutase
Synonyms EC SOD; Extracellular superoxide dismutase; Extracellular superoxide dismutase [Cu Zn]; Extracellular superoxide dismutase [Cu Zn] precursor; SOD 3; SOD3; Extracellular superoxide dismutases; Extracellular superoxide dismutase [Cu Zn]s…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
10559793 Yang JQ, Li S, Domann FE, Buettner GR, Oberley LW: Superoxide generation in v-Ha-ras-transduced human keratinocyte HaCaT cells. Mol Carcinog. 1999 Nov;26(3):180-8.

Superoxide generation was also inhibited by diphenylene iodonium, an inhibitor of flavoproteins, including NADPH oxidase, but not by rotenone, an inhibitor of the respiratory chain of the mitochondria.
Previous work has demonstrated that extracellular superoxide dismutase (SOD) can lower superoxide generation; this is the first report that intracellular SOD could also modify the amount of superoxide production from the cells.
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10486562 Hohler B, Lange B, Holzapfel B, Goldenberg A, Hanze J, Sell A, Testan H, Moller W, Kummer W: Hypoxic upregulation of tyrosine hydroxylase gene expression is paralleled, but not induced, by increased generation of reactive oxygen species in PC12 cells. FEBS Lett. 1999 Aug 20;457(1):53-6.


This increase is abolished by intracellular superoxide scavenging by Mn (III)-tetrakis (1-methyl-4-pyridyl)-porphyrin, and reduced or absent in the presence of the flavoprotein/complex I inhibitors, diphenyl-eneiodonium and rotenone.
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