| Name | EGFR |
|---|---|
| Synonyms | EGF receptor; EGFR; EGFR protein; ERBB; ERBB 1; ERBB1; Epidermal growth factor receptor; Epidermal growth factor receptor isoform a variant… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19339632 | Huang S, Zhang A, Ding G, Chen R: -induced mesangial cell proliferation is mediated by EGF receptor transactivation. Am J Physiol Renal Physiol. 2009 Jun;296(6):F1323-33. Epub 2009 Apr 1. Pretreatment with the antioxidant N-acetyl- catalase, SOD, mitochondrial respiratory chain complex I inhibitor rotenone (Rot), oxidase inhibitor apocynin, and DPI significantly inhibited Aldo-stimulated MC proliferation as well as EGFR transactivation. |
36(0,1,1,6) | Details |
| 20231142 | Villa-Abrille MC, Caldiz CI, Ennis IL, Nolly MB, Casarini MJ, Chiappe de Cingolani GE, Cingolani HE, Perez NG: The Anrep effect requires transactivation of the epidermal growth factor receptor. J Physiol. 2010 Mar 15. EGF increased O2- production by 149+/-4% of control (n=9, P <0.05), effect canceled by inhibiting oxidase (apocynin, 110+/-6% n=7), mKATP channels (5-HD, 105+/-5%, n=8), respiratory chain (rotenone, 110+/-7%, n=7) or MPTP (Cyclosporine, 111+/-10%, n=6). |
4(0,0,0,4) | Details |
| 17881465 | Ding G, Zhang A, Huang S, Pan X, Zhen G, Chen R, Yang T: ANG II induces c-Jun NH2-terminal kinase activation and proliferation of human mesangial cells via redox-sensitive transactivation of the EGFR. Am J Physiol Renal Physiol. 2007 Dec;293(6):F1889-97. Epub 2007 Sep 19. In contrast, inhibitors of other oxidant-producing enzymes, including the mitochondrial complex I inhibitor rotenone, the xanthine oxidase inhibitor allopurinol, the cyclooxygenase inhibitor indomethacin, the lipoxygenase inhibitor nordihydroguiaretic acid, the cytochrome P-450 oxygenase inhibitor ketoconazole, and the synthase inhibitor N (G)-nitro- methyl ester, were without effect. |
4(0,0,0,4) | Details |
| 15180991 | Chen K, Thomas SR, Albano A, Murphy MP, Keaney JF Jr: Mitochondrial function is required for peroxide-induced growth factor receptor transactivation and downstream signaling. J Biol Chem. 2004 Aug 13;279(33):35079-86. Epub 2004 Jun 4. We found that inhibition of flavin- or heme-containing proteins eliminated H (2) O (2)-induced transactivation of the epidermal growth factor receptor and stimulation of its downstream targets, JNK and Akt. Inhibition of mitochondrial function with rotenone, antimycin A, KCN, carbonylcyanide-m-chlorophenylhydrazone, or oligomycin reproduced this effect, as did generation of mitochondrial DNA-deficient (pseudo-rho (0)) cells. |
1(0,0,0,1) | Details |